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A standard definition of post-partum hemorrhage (PPH) considers the threshold of >500 mL blood loss for vaginal delivery and of >1,000 mL for caesarean section 13. Rates of PPH in Western Countries based on hospital discharge may range from 3 to 6%, while cases needing blood transfusion are as low as 1 % 10.
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Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
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May 15, 2024 · Pregnancy and childbirth. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman's health care providers to be aware that she has VWD so that plans can be made for a ...
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May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
Nov 30, 2009 · Introduction. Pregnancy and delivery are considered situations predisposing to a high risk of bleeding in women with von Willebrand’s disease (VWD). 1, 2 While patients with mild deficiency usually show a spontaneous complete correction of basal low factor VIII (FVIII) and von Willebrand factor (VWF) levels during pregnancy, patients with dysfunctional (type 2) or severe (type 3) VWD usually ...
Jan 10, 2022 · HMB is not the only challenge for women with VWD. 7 Pregnancy is associated with a higher VWF level in some women with VWD; typically those with type 1 VWD. The higher level, however, is not of the same magnitude as seen in pregnant women without VWD, resulting in an increased risk of primary postpartum hemorrhage (PPH) in patients with type 1 VWD. 8 Furthermore, the pregnancy-induced rise in ...
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related to: von willebrand in pregnancy causes and effects listVisit the HCP site to view safety information for a treatment for VWD in adults.
