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   Does von Willebrand disease affect pregnancy and delivery?

   • Given the wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms associated with the disorder, pregnancy and delivery in von Willebrand disease (VWD) represent a significant clinical challenge.

   PREGNANCY AND DELIVERY IN WOMEN WITH VON WILLEBRAND DISE…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7604852/

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   What is von Willebrand disease?

   • Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot properly. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should. Most people with the disease are born with it, having inherited it from one or both parents.

   Von Willebrand disease - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/von-willebrand-disease/symptoms-causes/syc-20354978

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   What are the risk factors for von Willebrand disease?

   • The main risk factor for von Willebrand disease is having a family history of it. Parents pass the gene for the disease to their children. Rarely, the disease skips generations. The disease is usually an "autosomal dominant inherited" disorder, which means you need a mutated gene from only one parent to get the disease.

   Von Willebrand disease - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/von-willebrand-disease/symptoms-causes/syc-20354978

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   Does von Willebrand disease cause clotting?

   • Many people with von Willebrand disease also have low levels of factor VIII, another protein that helps in clotting. Factor VIII is involved in another inherited clotting disorder called hemophilia. But unlike hemophilia, which mainly affects males, von Willebrand disease affects males and females and is usually milder.

   Von Willebrand disease - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/von-willebrand-disease/symptoms-causes/syc-20354978

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2. www.mayoclinic.org › diseases-conditions › vonVon Willebrand disease - Diagnosis & treatment - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › von

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   Oct 26, 2021 · Von Willebrand disease diagnosis & treatment. CON-XXXXXXXX. Learn more about the symptoms, causes, diagnosis, treatment of this inherited bleeding disorder in which blood doesn't clot well.

   • Symptoms & Causes

     The usual cause of von Willebrand disease is an inherited...

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     Von Willebrand disease. Learn more about the symptoms,...

3. www.ncbi.nlm.nih.gov › pmc › articlesPREGNANCY AND DELIVERY IN WOMEN WITH VON WILLEBRAND DISEASE

   www.ncbi.nlm.nih.gov › pmc › articles

   General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9, 17, 27, 31, treatment options should be planned at the beginning of pregnancy.

   • Author: Giancarlo Castaman, Paula D. James
   • DOI: 10.1111/ejh.13250

   • Publish Year: 2019
   • Published: 2019/08

4. www.cdc.gov › von-willebrand › femaleVon Willebrand Disease and Pregnancy

   www.cdc.gov › von-willebrand › female

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   May 15, 2024 · Key points. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery. Pregnancy and childbirth.

5. www.mayoclinicproceedings.org › article › S0025-6196Treatment of von Willebrand's Disease - Mayo Clinic Proceedings

   www.mayoclinicproceedings.org › article › S0025-6196

   Download Full Issue. Treatment of von Willebrand's Disease. LOUIS M. ALEDORT, M.D. DOI: https://doi.org/10.1016/S0025-6196 (12)61203-8. Treatment of von Willebrand's Disease. Early recognition that plasma infusions could correct the prolonged bleeding time and factor VIII deficiency in von Willebrand's disease (vWD) prompted major research efforts.

6. www.mayoclinicproceedings.org › article › S0025-6196Von Willebrand Factor: Structure and Function - Mayo Clinic ...

   www.mayoclinicproceedings.org › article › S0025-6196

   Von Willebrand factor (vWF) is an adhesive, multimeric glycoprotein present in plasma, platelets, and subendothelium, which has two main functions: (1) it serves as a carrier for factor VIII and (2) it plays a crucial role in platelet adhesion to subendothelium, acting as a “bridge” between platelet membrane glycoprotein (GP) Ib and GP IIb/IIIa ...