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May 16, 2016 · The carriers of either β° or severe β++ mutations have relatively high red blood cell count (RBC), while (MCV = hematocrit/RBC number) and mean corpuscular hemoglobin (MCH = Hb/RBC number) are markedly reduced (MCV: 60–70 fl; MCH: 19–23 pg). The Hb levels vary widely and they can be from normal to up to 2 g/dL.
- Overview
- What CBC findings indicate hemolytic anemia?
- What other tests can confirm hemolytic anemia?
- What can I expect after a diagnosis of hemolytic anemia?
- Frequently asked questions
- Takeaway
A complete blood count (CBC) might suggest hemolytic anemia if your RBC, hemoglobin, and reticulocyte counts are low. But further testing may be required.
Anemia occurs when you don’t have enough healthy red blood cells (RBCs) to transport oxygen throughout your body.
Hemolytic anemia is a subtype of anemia that is due to hemolysis, the breakdown of RBCs. Hemolytic anemia can be inherited or acquired.
A complete blood count (CBC) can provide information about how many RBCs you have and may also provide clues as to why your RBC count is low. Still, it’s usually not enough to confirm hemolytic anemia, so doctors often order further tests.
In this article, we explain how CBC results may indicate hemolytic anemia and what other testing may be required.
•fatigue, which may become extreme
A CBC is a simple blood test you may undergo in a healthcare setting, such as a doctor’s office or laboratory. Healthcare professionals use this test to measure and analyze RBCs, white blood cells (WBCs), and platelets.
These CBC measurements can help a healthcare professional determine if you have hemolytic anemia:
While a CBC can confirm anemia, a doctor will need other tests to confirm hemolytic anemia. These include:
•Peripheral blood smear: A blood smear can detect changes in RBC shape, which may indicate the type of anemia.
•Haptoglobin test: Haptoglobin is a protein that binds to free hemoglobin. A low haptoglobin count means you have too much hemoglobin not attached to RBCs, suggesting hemolytic anemia.
•Bilirubin test: Hemoglobin breaks down into bilirubin. A high bilirubin count suggests an increased breakdown of hemoglobin and possible hemolytic anemia.
•Lactase dehydrogenase (LDH) test: RBCs release LDH when they break down. A high LDH count typically suggests hemolysis.
•Hemoglobinuria test: This urine test can detect high levels of hemoglobin.
A healthcare professional will work with you on a treatment plan to reduce your risk of hemolysis. This may include strategies such as avoiding cold weather and staying warm indoors.
Reducing your risk of infection and illness will be important. A doctor may recommend getting annual vaccinations and avoiding large crowds. You may also need to avoid undercooked or raw food that can cause food-borne illnesses.
Treatments for hemolytic anemia vary based on the type you have and its underlying cause:
•If your immune system is producing antibodies that attack your RBCs, a doctor may recommend steroid therapy or immunosuppressive therapy.
•Intravenous (IV) medications, such as immunoglobulin (IVIG), may strengthen your immune system.
•If your condition is severe, a doctor may recommend treatments such as the surgical removal of your spleen or RBC transfusion.
Is a CBC enough to diagnose hemolytic anemia?
No. A CBC is helpful for diagnosing anemia and for providing information about the subtype you may have and its cause. Additional testing that includes other blood tests is required to make a definitive diagnosis of hemolytic anemia.
What is the most common cause of hemolytic anemia?
Sickle cell anemia is one of the most common causes of inherited hemolytic anemia. Autoimmune conditions are the most common cause of acquired hemolytic anemia.
What is the marker for autoimmune hemolytic anemia?
Doctors can detect autoimmune hemolytic anemia by the presence of autoantibodies in a direct Coombs test.
Hemolytic anemia is a subtype of anemia. A CBC is usually the first diagnostic test doctors use to diagnose this condition. If evidence of hemolytic anemia is found during a CBC, they’ll order further testing, such as haptoglobin, bilirubin, and LDH tests.
- Corey Whelan
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Sep 8, 2022 · MCHC stands for mean corpuscular hemoglobin concentration. It describes the level of hemoglobin in your red blood cells. Having low MCHC levels could mean you have anemia. It could also signify low iron, inflammation, or hemolysis. Symptoms of low MCHC include weakness, irregular heartbeat, and breathing problems.
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