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- Great progress has been made over the past years in elucidating the structure and function of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as antiviral targets. The structural proteins, which form the viral particle, include the core protein and the envelope glycoproteins E1 and E2.
pubmed.ncbi.nlm.nih.gov › 23463199Hepatitis C virus proteins: from structure to function - PubMed
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How does hepatitis C virus affect the liver?
What is hepatitis C virus (HCV)?
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Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus classified in the Hepacivirus genus within the Flaviviridae family. The Flaviviridae family includes yellow fever virus, West Nile virus, and dengue virus. The HCV particles are spherical and heterogenous in size, typically ranging 40-80 nm in diameter.
HCV contains a 9.6-kbp (+)ssRNA genome, expressing a single polyprotein that is cleaved into its 10 mature components by host and viral encoded proteases. In HCV, core (C) protein is expressed first, followed by the envelope (E) protein (s), an ion channel (p7), and then the nonstructural (NS) proteins.
- Altaira D. Dearborn, Joseph Marcotrigiano
- 10.1101/cshperspect.a036822
- 2020
- 2020/01
Structure of Hepatitis C Virus. The hepatitis C virus particle consists of a lipid membrane envelope that is 55 to 65 nm in diameter. [10] [11] Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. [12] They take part in viral attachment and entry into the cell. [10]
Dec 19, 2023 · Key points. Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). Many people with hepatitis C don't look or feel sick so might not know they have the virus. Left untreated, hepatitis C can lead to serious liver problems, like scarring and cancer. About Hepatitis C. Hepatitis C is a liver disease caused by HCV.
Feb 1, 2023 · Hepatitis C virus (HCV) is a spherical, enveloped, positive-stranded, single-stranded RNA virus with a diameter of 40–80 nm. It belongs to the Hepacivirus genus of the Flaviviridae family [ 1 ]. The nucleocapsid with icosahedral symmetry consists of genomic RNA and many copies of core proteins.
The viral genome of Hepatitis C virus is a single-stranded RNA that encodes 11 proteins. Hepatitis C viral structure The primary cells infected by Hepatitis C virus are liver cells called...
