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  1. Sep 11, 2023 · One of the main differences is that hemophilia primarily affects males, whereas VWD affects both females and males. Another difference is that VWD tends to be milder than hemophilia. If...

  2. May 11, 2024 · Causes. Von Willebrand Disease and Hemophilia are both inherited bleeding disorders, but they have different underlying causes. Von Willebrand Disease is caused by a deficiency or dysfunction of the von Willebrand factor (VWF), a protein that plays a crucial role in blood clotting.

  3. Feb 14, 2014 · Although similar, hemophilia and vWD have important differences. Bleeding location and severity vary more for vWD patients than for hemophilia patients. vWF targets skin and mucous membranes (the lining of the nose, mouth, intestines, uterus, and vagina), so a deficiency causes more bleeding at these sites.

  4. In type 2 N, there is impaired binding of VWF to factor VIII and significant reduction in factor VIII levels (ie, to 1 to 5%) similar to that seen in hemophilia A. Although VWD, like hemophilia A, is a hereditary disorder that may cause factor VIII deficiency, the factor VIII deficiency in VWD is usually only moderate (ie, to 20 to 40%).

  5. Jan 12, 2021 · Type 2N VWD can be mistaken for hemophilia A because of the low FVIII level, with critical treatment implications: patients with hemophilia A are treated with FVIII concentrate; however, type 2N VWD patients require VWF replacement therapy to prevent/treat serious bleeds.

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  7. FAST FACT. Type of VWD does not equal severity of VWD. Patients with VWD can experience a variety of bleeding symptoms—ranging from nosebleeds to joint bleeds—regardless of their VWD type. 2. There are 3 types of VWD—and some subtypes. 3. Type 1 Von Willebrand Disease. The body does not make enough von Willebrand factor (but it works properly)