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  1. Fentanyl: Fentanyl is a synthetic opioid and is said to be 30 to 50 times stronger than heroin. This prescription medication is used to treat severe pain after surgery and chronic pain in opioid-dependent people. Fentanyl is responsible for the vast majority of opioid overdose deaths. Hydromorphone and oxymorphone:

    • Nonsteroidal anti-inflammatory drugs, known as NSAIDs. NSAIDs are most effective for mild to moderate pain that occurs with swelling and inflammation. These medications are commonly used for arthritis and pain resulting from muscle sprains, strains, back and neck injuries, or menstrual cramps.
    • Acetaminophen. Acetaminophen is usually recommended as a first line treatment for mild to moderate pain. It might be taken for pain due to a skin injury, headache, or conditions that affect the muscles and bones.
    • COX-2 inhibitors. COX-2 inhibitors are another type of NSAID. These medications were developed with the aim of reducing the common side effects of traditional NSAIDs.
    • Antidepressants and anti-seizure medications. Some medications commonly prescribed to manage depression and prevent epileptic seizures have been found to help relieve chronic pain.
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  3. Mar 14, 2024 · Examples of pain-relieving anti-seizure medications include gabapentin (Neurontin, Gralise) and pregabalin (Lyrica). Side effects of these medications are common and may include nausea, dizziness, drowsiness and a sense of tiredness. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include ibuprofen (Advil, Motrin IB ...

  4. May 24, 2022 · Opioids Used to Treat Chronic Pain . Codeine: Codeine is a pain medication that is taken by mouth. It is short-acting, meaning it lasts only for a few hours per dose. Codeine is often combined with acetaminophen though it may also be administered with aspirin. Oxycodone: Oxycodone is available in both a short-acting and long-acting pain ...

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  5. Jul 22, 2022 · baclofen (Lioresal) Trusted Source. tizanidine (Zanaflex) dantrolene ( Dantrium, Revonto, and Ryanodex) Some side effects vary between different antispastics but generally include muscle weakness ...

  6. Mar 22, 2023 · What Is the Best Pain Medication for Chronic Pain? OTC chronic pain medications. Prescription pain medications. Most common treatment. Summary. Identifying the best medication for chronic...

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