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  1. There are no routine tests to make the diagnosis or to identify the culprit drug. Differential diagnosis includes measles, rubella, scarlet fever, non-specific toxic erythema associated with infection, Kawasaki disease, connective tissue disease and acute graft-versus-host disease.

  2. dermnetnz.org › topics › drug-eruptionsDrug eruptions | DermNet

    Acute or subacute adverse cutaneous reactions to a drug or medicine include drug eruptions. There are many types of drug eruption, which range from a clinically mild and unnoticed rash to a severe cutaneous adverse reaction (SCAR) that may be life-threatening.

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  4. Many antibiotics cause morbilliform eruptions. A morbilliform rash usually starts within 7–14 days of starting a new antibiotic, and lasts for 5–10 days. It may occur more quickly on re-exposure to the same drug. It can look similar to a viral exanthem but is usually pruritic, whereas similar viral rashes are not particularly itchy.

  5. Morbilliform drug eruption; Drug hypersensitivity syndrome. Acute connective tissue diseases can present with an exanthem: Systemic lupus erythematosus; Systemic-onset juvenile arthritis; Adult-onset Still disease. Some exanthems are of unknown cause, for example, Kawasaki disease. What are the signs and symptoms of exanthems?

  6. Rubelliform eruption (rash looks like rubella): E2; Morbilliform eruption (rash looks like measles): E6, E11, E25; Petechiae (tiny purple spots or purpura): E11, E19; Punctate macular eruption: E19; A vesicular eruption (blisters): E11; Eczema coxsackium (a severe infection associated with atopic dermatitis). See enteroviral images.

  7. Acute measles is usually confirmed on a viral nasopharyngeal or throat swab analysed by polymerase chain reaction (PCR). Blood and urine samples can also be used. This should be done within 5 days of onset of rash, however, positive results are sometimes obtained up to 10–14 days after the rash has resolved.

  8. This topic provides a differential diagnosis for urticaria and for urticaria-like conditions that resemble urticaria but are not caused by wealing. What is urticaria? Urticaria describes a group of conditions in which there are weals (or weals) in the skin, itchy white or red lumps.

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