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Ampicillin/sulbactam is a fixed-dose combination medication of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist.
Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.
Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. [7]
Jan 11, 2024 · The ampicillin/sulbactam combination demonstrates synergy in addressing bacterial strains resistant to ampicillin, thus providing broader coverage. This drug combination incorporates a β-lactamase inhibitor into ampicillin, extending coverage against potentially resistant bacteria.
- Basil V. Peechakara, Mohit Gupta
- 2024/01/11
- Cleveland Clinic Foundation
Ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.
Oct 27, 2023 · Ampicillin and sulbactam are penicillin antibiotics that fight bacteria. Ampicillin and sulbactam is a combination medicine used to treat many different types of infections caused by bacteria. Ampicillin and sulbactam may also be used for purposes not listed in this medication guide.
Ampicillin/Sulbactam is a prescription medication used to treat the symptoms of bacterial infections such as Gynecologic Infections, Intra-Abdominal Infections, Skin and Skin Structure Infections, Orbital Cellulitis, Pelvic Inflammatory Disease, Pneumonia, and Urinary Tract Infections.
