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  1. A COVID‑19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), the virus that causes coronavirus disease 2019 ( COVID‑19 ). Prior to the COVID‑19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing ...

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  3. v. t. e. The Novavax COVID-19 vaccine, sold under the brand names Nuvaxovid and Covovax, [1] among others, is a subunit COVID-19 vaccine developed by Novavax and the Coalition for Epidemic Preparedness Innovations (CEPI).

  4. Jun 6, 2021 · The strategy we propose here for the production of a fusion vaccine directed against COVID-19 features a number of convenient points. First, the use of E. coli as the microbial host for the overexpression of a subunit vaccine implies a fast and robust process when compared with fermentations requiring other microorganisms or higher-organism ...

    • Maria Laura Bellone, Andrea Puglisi, Fabrizio Dal Piaz, Alejandro Hochkoeppler, Alejandro Hochkoeppl...
    • 10.1016/j.bbrc.2021.04.056
    • 2021
    • 2021/06/06
  5. Jun 18, 2021 · Production in Escherichia coli of recombinant COVID-19 spike protein fragments fused to CRM197. Biochem Biophys Res Commun. 2021 Jun 18:558:79-85. doi: 10.1016/j.bbrc.2021.04.056. Epub 2021 Apr 20. Authors. Maria Laura Bellone 1 , Andrea Puglisi 2 , Fabrizio Dal Piaz 3 , Alejandro Hochkoeppler 4. Affiliations.

    • Maria Laura Bellone, Andrea Puglisi, Fabrizio Dal Piaz, Alejandro Hochkoeppler, Alejandro Hochkoeppl...
    • 2021
  6. Mar 23, 2022 · As of February 8, 2022, WHO reported 337 COVID-19 vaccine candidates currently under development, of which 47 are mRNA vaccines, and 23 among these have entered clinical trials. 100 The mRNA ...

  7. Type and morphology. E. coli is a gram-negative, facultative anaerobe, nonsporulating coliform bacterium. Cells are typically rod-shaped, and are about 2.0 μm long and 0.25–1.0 μm in diameter, with a cell volume of 0.6–0.7 μm 3.

  8. Aug 31, 2021 · Plasmids are used in mRNA vaccine production because they are easy to replicate (copy) and reliably contain the target gene sequence. Once a sequence is selected, a new plasmid can be produced within a couple of weeks, allowing new mRNA vaccines to be tested and distributed rapidly. Researchers then use established in-vitro (laboratory-based ...

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