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The envelope (E) protein is the smallest and least well-characterized of the four major structural proteins found in coronavirus virions. It is an integral membrane protein less than 110 amino acid residues long; in SARS-CoV-2, the causative agent of Covid-19, the E protein is 75 residues long.
May 27, 2019 · The CoV envelope (E) protein is a small, integral membrane protein involved in several aspects of the virus’ life cycle, such as assembly, budding, envelope formation, and pathogenesis. Recent studies have expanded on its structural motifs and topology, its functions as an ion-channelling viroporin, and its interactions with both other CoV ...
- Dewald Schoeman, Burtram C. Fielding
- 2019
May 27, 2019 · The CoV envelope (E) protein is a small, integral membrane protein involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. Recent studies have expanded on its structural motifs and topology, its functions as an ion-channelling viroporin, and its interactions with both other CoV ...
- Dewald Schoeman, Burtram C. Fielding
- 2019
May 27, 2019 · The CoV envelope (E) protein is a small, integral membrane protein involved in several aspects of the virus’ life cycle, such as assembly, budding, envelope formation, and pathogenesis. Recent studies have expanded on its structural motifs and topology, its functions as an ion-channelling viroporin, and its interactions with both other CoV ...
- Dewald Schoeman, Burtram C. Fielding
- 10.1186/s12985-019-1182-0
- 2019
- Virol J. 2019; 16: 69.
Nov 11, 2020 · 227 Citations. 295 Altmetric. Metrics. Abstract. An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus...
- Venkata S. Mandala, Matthew J. McKay, Alexander A. Shcherbakov, Aurelio J. Dregni, Antonios Kolocour...
- 2020
Oct 13, 2023 · The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The calcium channel activity of E is associated with the inflammatory responses of COVID-19.
Jun 10, 2021 · Open access. Published: 10 June 2021. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Bingqing...
