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Aedes albopictus is a secondary dengue vector in Asia. Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death. Dengue should be suspected when a high fever (40°C/ 104°F) is accompanied by two of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains ...
Summary Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock.
- Characteristics of The Children
- Clinical Manifestations of The Children
- Determinants of Severity Among Children
Out of 190 pediatric dengue patients, 179 (94.2%) cases were positive for NS1 antigen, and 11 (5.8%) cases for IgM antibody. Overall, children with dengue had an average age of 8.8 ± 3.7 years with a slight male predominance (1.22:1). However, severe cases showed slightly male predominance. The majority (46.1%) of the children belonged to the age g...
Symptoms
Table 2 enlists the frequently occurring general, systematic and unusual clinical presentation of children in relation to severity. Additional less frequent freatures are described in Table S2 (Additional file 1). All of the children presented with fever. The average maximum recorded temperature was 103.3 F (SD ± 1.2). The average duration of fever was 5.4 days (SD ± 2.8). However, it was significantly higher in patients with severe disease than non-severe (6.2 ± 4.1 vs. 5.1 ± 2.0 days, p0.04...
Atypical symptoms
Several atypical manifestations were noted among patients with most frequent being confusion (21.4%), and blurring of vision (14.9%) (Table 2). Additionally, palpitation (11.9%), chest tightness (9.8%), sensory impairment (9.7%), convulsion (7.0%), disorientation (5.9%), neck stiffness (5.9%), palpable lymph nodes (3.1%), auditory hallucination (2.7%), transient amnesia (1.6%), altered mental state (1.6%) and facial deviation (0.5%) occurred infrequently among participants (Table S2). All the...
Signs
Among features of plasma leakage and shock, cold-clammy skin (47.5%) and excessive sweating (40.8%) were most prominent. Moreover, 15.8% of children had obvious manifestations of clinical fluid accumulation (Table 2). Ascites, pleural effusion, and anasarca were present in 6.8, 5.8 and 2.6% patients respectively. While anemia and dehydration were found in 15.1 and 11.9% of children, respectively. Only three children had hepatomegaly (1.8%) (Table S2).
Factors which differed among children in relation to age, sex and severity were included in a predictive model to determine their predictive values for severe dengue among children (Table 4). These included child’s age, sex, certain clinical features (backache, retroorbital pain, oral ulcer, rash, arthralgia, vomiting, abdominal pain, loose motion,...
- Md. Abdullah Saeed Khan, Abdullah Al Mosabbir, Enayetur Raheem, Ahsan Ahmed, Rashawan Raziur Rouf, M...
- 2021
Mar 6, 2024 · A fraction of infections, between 0.5% and 5%, develop into severe dengue. Without proper treatment, fatality rates may exceed 20%, particularly among children. The typical incubation period for the disease is 4 to 7 days, with symptoms lasting from 3 to 10 days.
- 2024/03/06
Clinical Characteristics and Risk Factors of Dengue Shock Syndrome in Children. Dolores Lovera, MD,*† Celia Martinez de Cuellar, MD, MSc,*† Soraya Araya, MD,* Sara Amarilla, MD,*† Nicolás Gonzalez, MD,*† Carlos Aguiar, MD,* Julia Acuña, MD,*† and Antonio Arbo, MD, MSc*†.
This virus-antibody complex allows for enhanced viral entry into host cells, specifically dendritic cells and macrophages. Once inside the cell, the virus replicates and generates higher virus titers in the blood than when anti-DENV antibody is not present, which results in a “cytokine storm” and ultimately leading to more severe disease.
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