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Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 10.1007/s00284-020-02284-w
- 2021
- Curr Microbiol. 2021; 78(1): 17-32.
Feb 17, 2022 · Abstract. Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane ...
- Qingxin Li, Congbao Kang
- Membranes (Basel). 2022 Feb; 12(2): 231.
- 10.3390/membranes12020231
- 2022/02
Jul 25, 2017 · However, preventive strategies for DENV have been developed in the form of vector control, including chemical, biological, and physical controls. Apart from general control strategies, development of vaccines have offered effective prevention and control of this disease (DeRoeck et al., 2003 ). Figure 1. Dengue virus infection.
Apr 22, 2024 · This intricate interplay between the virus and the host’s translation machinery is crucial for the successful propagation of the virus within the host cell. Upon infection, the Dengue virus genome, a positive-sense single-stranded RNA, serves as a template for the translation of viral proteins.
The Plan includes the following key features – (a) three-tier response level system with each level representing a graded risk of DF affecting Hong Kong and its health impact on the community; (b) key factors to be considered in the risk assessment; (c) activation and standing down mechanism;
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Summary of mode of action: TDV contains live attenuated dengue viruses. The primary mechanism of action of TDV is to replicate locally and elicit humoral and cellular immune responses against dengue disease caused by any of the four dengue virus serotypes. Important information about its composition: Dengue tetravalent vaccine is a live ...
