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Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.
- 10.3390/v15030705
- 2023/03
- Viruses. 2023 Mar; 15(3): 705.
Mar 1, 2017 · Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue.
- Jenny Guek Hong Low, Eng Eong Ooi, Subhash G. Vasudevan
- 10.1093/infdis/jiw423
- 2017
- 2017/03/03
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Apr 18, 2023 · Dengue viruses (DENV) continue to circulate worldwide, resulting in a significant burden on human health. There are four antigenically distinct serotypes of DENV, an infection of which could result in a potentially life-threatening disease. Current treatment options are limited and rely on supportive care.
- 10.1007/s40506-023-00263-w
- 2023
Oct 5, 2021 · In this review, the possible drug targets for discovery and development of potential antiviral drugs against structural proteins of dengue virus, the current development status of the antiviral drugs against dengue around the world, and challenges that need to be addressed to overcome the shortcomings in the process of drug discovery have been d...
- Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh
- 2021
Oct 6, 2021 · Summary: Researchers have developed an ultrapotent inhibitor of the dengue virus, which causes the tropical disease known as dengue. The antiviral molecule is exceptionally effective against...
Oct 5, 2021 · Structural proteins are building blocks of viruses, targeting them to weaken the virus and eventually kills it. Therefore can be a promising drug target for treating dengue viral infections. •. Envelope proteins are one of the widely studied structural proteins and are the most promising anti-dengue drug target. •.
Oct 6, 2021 · An effective drug against dengue virus (DENV) is urgently needed, because this mosquito-transmitted virus represents a tremendous public-health burden, with about 3.9 billion people at risk of ...
