Yahoo Web Search

Sign In

Search results

  1. www.ncbi.nlm.nih.gov › pmc › articlesGenetic contributions to autism spectrum disorder - PMC

    Feb 26, 2021 · CNVs can impact one or multiple genes and can occur at common or rare frequencies in a population. All CNVs associated with autism have been rare. Recurrent CNVs are among the most convincing rare inherited risk variations for autism, and have a prevalence of about 3% in affected patients (Bourgeron, 2016).

    • Fig. 1

      Relative risk of autism by degree of relatedness with a...

  2. www.ncbi.nlm.nih.gov › pmc › articlesBiological implications of genetic variations in autism ...

    Jul 7, 2021 · The heritability of autism in addictive genetic effect (rare inherited and common inherited) is estimated to be 52%, and the non-additive genetic effect is approx. 7% including de novo mutations and non-additive effects [4,44]. To ascertain the genetic basis of ASD, more attention should be paid on the non-coding regions of the genome structure.

    • Yue Zhang, Xuanshi Liu, Ruolan Guo, Wenjian Xu, Qi Guo, Chanjuan Hao, Xin Ni, Wei Li
    • 10.1042/BSR20210593
    • 2021
    • Biosci Rep. 2021 Jul 30; 41(7): BSR20210593.

  3. People also ask

  4. www.nature.com › articles › s41398/022/02009-6Genetics of autism spectrum disorder: an umbrella review of ...

    Jun 15, 2022 · To date, numerous studies have investigated the associations between genetic variants and ASD risk. To provide a robust synthesis of published evidence of candidate gene studies for ASD, we...

  5. www.nature.com › articles › s41588/022/01064-5A phenotypic spectrum of autism is attributable to the ...

    Jun 2, 2022 · In a large family sample, we show that genetic loads of rare and polygenic risk are inversely correlated in cases and greater in females than in males, consistent with a liability threshold...

  6. Videos

    View all

  7. www.nature.com › articles › s10038/022/01076-3Genetics of autism spectrum disorders and future direction

    Aug 30, 2022 · Common genetic variants. ASD is not always induced by common genetic variants alone, with less of an impact of genes than rare variants. While rare variants have a very low prevalence...

  8. bmcneurosci.biomedcentral.com › articles › 10A systematic review of common genetic variation and ...

    Oct 9, 2021 · Increasing evidence suggests that the bulk of genetic risk associated with ASD may be due to single nucleotide polymorphisms (SNPs) and copy number variants (CNVs), rather than specific single-gene mutations or syndromic conditions, which constitute only approximately 5–15% of ASD cases [ 5 ].