Search results
Jul 7, 2021 · According to the Centers for Disease Control and Prevention (U.S.A.), the prevalence of ASD is approx. 1:54, with a significantly higher proportion of males affected compared with females [ 2 ]. ASD is a complex and highly inheritable disease.
- Table 2
National Center for Biotechnology Information
- PMC Free Article
Introduction. Adult hippocampal neurogenesis, a unique form...
- Table 2
Feb 26, 2021 · The clinical heterogeneity of autism is mirrored by a complex genetic architecture involving several types of common and rare variants, ranging from point mutations to large copy number variants, and either inherited or spontaneous ( de novo ).
- A. Havdahl, A. Havdahl, M. Niarchou, A. Starnawska, A. Starnawska, M. Uddin, C. van der Merwe, V. Wa...
- 10.1017/S0033291721000192
- 2021
- Psychol Med. 2021 Oct; 51(13): 2260-2273.
Aug 30, 2022 · A significant inheritance pattern in ASD involves a rare genetic mutation; common copy number variants refer to duplication or deletion of stretches of chromosomal loci or protein-disrupting...
- Yuka Yasuda
People also ask
Can autism genetics detect common and rare genetic variation?
Does genetic variation affect autism risk?
What is the genetic risk for autism?
Jun 15, 2022 · To date, numerous studies investigating the association between genetic variants and ASD risk have been published [ 9, 10, 11 ]. Most of these studies focused on identifying single nucleotide...
Jul 30, 2023 · The researchers also examined polygenic risk, in which a combination of commonly found genetic variations can raise the likelihood of developing autism. They found children who inherit rare mutations from unaffected parents in combination with polygenic risk are more likely to have autism.
About 52 percent of the risk for autism was traced to common and rare inherited variation, with spontaneous mutations contributing a modest 2.6 percent of the total risk.
Oct 9, 2021 · Increasing evidence suggests that the bulk of genetic risk associated with ASD may be due to single nucleotide polymorphisms (SNPs) and copy number variants (CNVs), rather than specific single-gene mutations or syndromic conditions, which constitute only approximately 5–15% of ASD cases [ 5 ].
