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- About 52 percent of the risk for autism was traced to common and rare inherited variation, with spontaneous mutations contributing a modest 2.6 percent of the total risk.
www.nih.gov › news-events › news-releasesCommon gene variants account for most genetic risk for autism
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About 52 percent of the risk for autism was traced to common and rare inherited variation, with spontaneous mutations contributing a modest 2.6 percent of the total risk.
- Genetic contributions to autism spectrum disorder - PMC
Overall, methylomic studies of autism provide increasing...
- Autism Genetics: Over 100 Risk Genes and Counting - PMC
Although most of the genetic risk in ASD is due to common...
- Genetic contributions to autism spectrum disorder - PMC
Jul 7, 2021 · Several significant common risk loci delineating the genetic heterogeneity of phenotypic subgroups have been found to reveal that common variants play a large role in high-functioning autism.
- Yue Zhang, Xuanshi Liu, Ruolan Guo, Wenjian Xu, Qi Guo, Chanjuan Hao, Xin Ni, Wei Li
- 10.1042/BSR20210593
- 2021
- Biosci Rep. 2021 Jul 30; 41(7): BSR20210593.
Jul 30, 2023 · Autism is highly heritable: It is estimated at least 50% of genetic risk is predicted by common genetic variation and another 15-20% is due to spontaneous mutations or predictable inheritance patterns. The remaining genetic risk is yet to be determined.
Feb 25, 2019 · Interestingly, both common and rare variation in ASD preferentially affects genes expressed during corticogenesis 31, thus highlighting a potential spatiotemporal convergence of genetic risk on...
Jun 2, 2022 · In a large family sample, we show that genetic loads of rare and polygenic risk are inversely correlated in cases and greater in females than in males, consistent with a liability threshold...
