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How selenocysteine is encoded in selenoprotein mRNA?
What is selenocysteine (Sec)?
How is selenocysteine encoded?
What is selenocysteine tRNA synthetase (SerRS)?
Oct 9, 2012 · Emerging evidence suggests that enzymes responsible for selenocysteine formation and decoding the selenocysteine UGA codon, which by extension are critical for synthesis of the entire selenoproteome, are essential for the development and health of the human organism.
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The essentiality of the selenocysteine cycle has also been...
- Table 1
Txnrd1 and 2 – Housekeeping proteins Txnrd3 – Expressed in...
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Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Figure 4
Nov 25, 2021 · Firstly, in prokaryotes, SelC is catalyzed by Seryl-tRNA synthetase (SerS) to load Ser to form Ser-tRNA [Ser]Sec. Secondly, as the key conversion compound between inorganic selenium and organic selenium, hydrogen Selenophosphate (H-Se − ) is the primary source of selenium.
- 10.3390/molecules26237120
- 2021/12
- Molecules. 2021 Dec; 26(23): 7120.
A selenocysteine residue is encoded by the UGA codon in selenoprotein mRNA , which is decoded by selenocysteyl-tRNA [Ser]Sec [ 3 , 4 ]. The selenocysteine moiety on selenocysteyl-tRNA [Ser]Sec is biosynthesized using selenophosphate , which is produced from selenide and ATP by selenophosphate synthetase [ 5 , 6 ].
In eukaryotes and archaea, two enzymes are required to convert tRNA-bound seryl residue into tRNA selenocysteinyl residue: PSTK (O-phosphoseryl-tRNA[Ser]Sec kinase) and selenocysteine synthase.
Mar 10, 2011 · Sec tRNA, designated tRNA [Ser]Sec, is initially aminoacylated with serine by seryl-tRNA synthetase and the resulting seryl moiety is converted to phosphoserine by O -phosphoseryl-tRNA kinase to form O -phosphoseryl-tRNA [Ser]Sec. Sec synthase (SecS) then uses O -phosphoseryl-tRNA [Ser]Sec and the active donor of selenium, selenophosphate, to fo...
- Anton A. Turanov, Xue-Ming Xu, Bradley A. Carlson, Min-Hyuk Yoo, Vadim N. Gladyshev, Dolph L. Hatfie...
- 10.3945/an.110.000265
- 2011
- Adv Nutr. 2011 Mar; 2(2): 122-128.
Nov 15, 2022 · In bacteria, Ser-tRNA Sec is converted to Sec-tRNA Sec in a single step by selenocysteine synthase (SelA). In eukaryotes this process occurs in two separate steps: i) phosphorylation of Ser by O -phosphoseryl-tRNA kinase (PSTK) then ii) conversion of phosphoserine (Sep) to Sec by Sep-tRNA:Sec-tRNA synthase (SepSecS).
Oct 11, 2011 · The key steps in the replacement of Sec with Cys are: (1) sulfide can substitute for selenide in the SPS2 catalyzed reaction yielding thiophosphate; and (2) thiophosphate can react with the O-phosphoseryl-tRNA [Ser]Sec intermediate which is most likely dehydroalanine that was generated by the interaction of SecS to yield Sec tRNA [Ser]Sec (Fig ...
