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  1. www.ncbi.nlm.nih.gov › pmc › articlesSynthesis and decoding of selenocysteine and human health

    Oct 9, 2012 · Emerging evidence suggests that enzymes responsible for selenocysteine formation and decoding the selenocysteine UGA codon, which by extension are critical for synthesis of the entire selenoproteome, are essential for the development and health of the human organism.

    • Figure 4

      The essentiality of the selenocysteine cycle has also been...

    • Table 1

      Table 1. Human selenoproteins, physiological role, and...

    • Open in a Separate Window

      Point mutations in SepSecS give rise to progressive...

  2. en.wikipedia.org › wiki › SelenocysteineSelenocysteine - Wikipedia

    In eukaryotes and archaea, two enzymes are required to convert tRNA-bound seryl residue into tRNA selenocysteinyl residue: PSTK (O-phosphoseryl-tRNA[Ser]Sec kinase) and selenocysteine synthase.

  3. www.ncbi.nlm.nih.gov › pmc › articlesSelenoproteins: Molecular Pathways and Physiological Roles

    Although selenoproteins represent diverse molecular pathways and biological functions, all these proteins contain at least one selenocysteine (Sec), a selenium-containing amino acid, and most serve oxidoreductase functions.

  4. www.ncbi.nlm.nih.gov › pmc › articlesThe Molecular Biology of Selenocysteine - PMC

    Aug 1, 2013 · Interestingly, a single Sec residue resides in the N-terminus while the remaining are primarily located in the C-terminus . The N-terminus of SelP has been shown to have potential weak antioxidant role while the C-terminus is essential for selenium distribution (65,131).

    • Jonathan N. Gonzalez-Flores, Sumangala P. Shetty, Aditi Dubey, Paul R. Copeland
    • 10.1515/bmc-2013-0007
    • 2013
    • 2013/08/08

  5. www.sciencedirect.com › science › articleSelenocysteine in proteins—properties and biotechnological use

    Oct 30, 2005 · All of the methods are based on either the introduction of a selenium isotope, with specific characteristics such as high-energy radioactivity (as for 75 Se and 73 Se) or uncommon nuclear spin ( 77 Se), or on the high reactivity of a Sec residue in comparison to Cys. Table 5.

    • Linda Johansson, Guro Gafvelin, Elias S.J. Arnér
    • 2005

  6. bioportal.bioontology.org › ontologies › PSIMODProtein Modification Ontology - L-selenocysteine (Ser ...

    For encoded L-selenocysteine, use MOD:00031 [JSG]. A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process).

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  8. www.sciencedirect.com › science › articleThe selenocysteine toolbox: A guide to studying the 21st ...

    Nov 15, 2022 · In bacteria, Ser-tRNA Sec is converted to Sec-tRNA Sec in a single step by selenocysteine synthase (SelA). In eukaryotes this process occurs in two separate steps: i) phosphorylation of Ser by O -phosphoseryl-tRNA kinase (PSTK) then ii) conversion of phosphoserine (Sep) to Sec by Sep-tRNA:Sec-tRNA synthase (SepSecS).