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  1. Oct 27, 2022 · Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.

    • Figure 2

      Background: Over the years, forensic pathology has...

    • Table 2

      Background: Over the years, forensic pathology has...

    • Two Case Reports

      Introduction. Hemoglobins can be classified into two groups:...

  2. Mar 17, 2022 · Sodium nitrite causes methemoglobinemia and hypotension. The recommended treatment of sodium nitrite and resultant methemoglobinemia is intravenous methylene blue. The dose is typically 1–2 mg/kg intravenously over 5 minutes, 8 with a maximum dose of 7 mg/kg, even in cases of severe methemoglobinemia.

    • 10.1002/emp2.12702
    • 2022/04
  3. Jul 15, 2023 · Nausea. Fatigue. Rapid heart rate. Loss of consciousness. Confusion. Dizziness. A blue color on the skin and lips. Sodium nitrite poisoning can also cause diarrhea and pain in your belly. Call 911 ...

  4. Abstract. Sodium nitrite is a powerful oxidizing agent that causes hypotension and limits oxygen transport and delivery in the body through the formation of methemoglobin. Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death.

    • Matthew R. Neth, Jennifer S. Love, B. Zane Horowitz, Michael D. Shertz, Ritu Sahni, Mohamud R. Daya
    • 2021
  5. Spinach, cauliflower, collard greens, beets, and broccoli are naturally high in nitrates. Nitrates and nitrites are made up of nitrogen and oxygen and can combine with other compounds like sodium and ammonium. Sodium nitrate is commonly used as a preservative in curing meats and ammonium nitrate is found in instant cold packets.

  6. The dose may be repeated at 1 mg/kg if MetHb does not resolve within 30 minutes. Methylene blue should reduce MetHb levels significantly in less than an hour. It does this by acting as a cofactor to increase the activity of NADPH-MetHb reductase [Skold et al. 2011; McDonagh et al. 2013] (See Figure 6).

  7. Jan 22, 2024 · The annual suicide rate using sodium nitrite increased from 0.01–0.09/100,000 person-years over the three-year period. Online forums were used to share knowledge on the procurement and preparation of sodium nitrite poisoning. Conclusions. Sodium nitrite self-poisoning is an increasingly used planned suicide method among young people.

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