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  1. www.ncbi.nlm.nih.gov › pmc › articlesTherapeutic hypothermia for acute brain injuries - PMC

    Jun 5, 2015 · History. Therapeutic hypothermia for acute brain injury is the intentional lowering of body temperature, with the objective of reducing tissue damage in the central nervous system. Modern use of therapeutic hypothermia as a neuroprotective strategy began in the 1940s with the work of Fay [ 1 ], who reported the first series of patients with ...

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      Therapeutic hypothermia, recently termed target temperature...

    • PMC Free Article

      Background: The role of admission blood glucose level on the...

  2. www.thelancet.com › journals › eclinmSafety and efficacy of long-term mild hypothermia for severe ...

    Jan 28, 2021 · A recent Cochrane review of hypothermia for treatment of severe brain injury, identified 37 randomized clinical trials involving 3110 patients. We further identified one trial that compared the efficacy of hypothermia treatment with control in 387 patients.

    • Jiyuan Hui, Junfeng Feng, Yue Tu, Weituo Zhang, Chunlong Zhong, Min Liu, Yuhai Wang, Liansheng Long,...
    • 2021

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  4. www.nejm.org › doi › fullHypothermia for Intracranial Hypertension after Traumatic ...

    Dec 17, 2015 · Peterson, K, Carson, S, Carney, N. Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis. J Neurotrauma 2008;25:62-71 Crossref

    • Ronan O'Leary, Peter J A Hutchinson, David Menon
    • 2015

  5. www.nature.com › articles › nrneurolHypothermia for acute brain injury—mechanisms and practical ...

    Feb 28, 2012 · Treatment of traumatic brain injury with moderate hypothermia. N. Engl. J. Med. 336, 540–546 (1997). Article CAS PubMed Google Scholar Clifton, G. L. et al. Very early hypothermia induction in ...

    • H. Alex Choi, Neeraj Badjatia, Stephan A. Mayer
    • 2012

  6. www.ncbi.nlm.nih.gov › pmc › articlesTherapeutic Hypothermia and Targeted Temperature Management ...

    Jun 1, 2016 · The Prophylactic Hypothermia Trial to Lessen Brain Injury (POLAR) may provide valuable data to support this hypothesis (Nichol et al., 2015). In addition, the Long-term Mild Hypothermia for severe traumatic brain injury (LTH-1) trial will test whether hypothermia for 5 days is beneficial (Lei et al., 2015).

    • W. Dalton Dietrich, Helen M. Bramlett
    • 2016

  7. ccforum.biomedcentral.com › articles › 10A meta-analysis of the effects of therapeutic hypothermia in ...

    Dec 5, 2019 · Purpose Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of therapeutic hypothermia management in patients with traumatic brain injury. Methods We searched the Web of Science, PubMed, Embase, Cochrane (Central) and Clinical Trials databases from inception to January 17, 2019 ...

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  9. www.ncbi.nlm.nih.gov › pmc › articlesHypothermia for traumatic brain injury - PMC

    Sep 21, 2017 · Mild to moderate hypothermia, cooling to 32 to 35 ºC, has been used in the treatment of brain injury for over 50 years . Although there were several promising experimental studies ( Clasen 1968 ; Laskowski 1960 ) and case series ( Sedzimir 1959 ; Shapiro 1974 ), no controlled clinical studies were performed and the therapy fell from favour.

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