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Jun 6, 2021 · In the last decade, microbiome research has begun to advance our understanding of how the microbiome at multiple colonization sites (lung, skin, gut) influences the immune dysregulation that develops during sepsis.
- William D Miller, Robert Keskey, John C Alverdy
- 10.1093/infdis/jiaa682
- 2021
- 2021/06/06
Aug 14, 2021 · Introduction. It is estimated that ≈1.7 million patients in the United States annually will succumb to an episode of sepsis, which is defined as life-threatening organ dysfunction caused by the dysregulated host response to infection [ 1 ].
- Hansol Kang, Ryan M. Thomas
- 10.3390/jcm10163578
- 2021
- J Clin Med. 2021 Aug; 10(16): 3578.
Oct 26, 2021 · Sepsis occurs due to impaired activation of the immune system in response to infection; therefore, its onset depends on microbial pathogen-associated molecular patterns (PAMPs) that are recognized by pattern-recognition receptors (PRRs).
- Mengwei Niu, Peng Chen
- 10.1093/burnst/tkab036
- 2021
- Burns Trauma. 2021; 9: tkab036.
Dec 2, 2022 · Tom van der Poll. Open Access Published: December 02, 2022 DOI: https://doi.org/10.1016/j.ebiom.2022.104363. PlumX Metrics. Summary. Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality worldwide.
Jun 1, 2021 · Introduction. Sepsis resulting from bacterial bloodstream infections remains a serious clinical concern and is currently defined as a “life-threatening organ dysfunction caused by a dysregulated immune response that occurs as the result of an infection” ( 1 ).
Jun 16, 2021 · PMCID: PMC8206800. DOI: 10.1093/infdis/jiaa682. Abstract. Sepsis has been characterized as a dysregulated host response to infection, and the role of the microbiome as a key influencer of this response is emerging. Disruption of the microbiome while treating sepsis with antibiotics can itself result in immune dysregulation.
Dec 13, 2018 · Sepsis is a life-threatening condition initiated by an infection that causes systemic inflammation, and is a major cause of morbidity and mortality in the neonatal population in the developing ...
