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Oct 6, 2023 · tPA is a drug that dissolves blood clots in the brain and restores blood flow after a stroke. Learn about its benefits, risks, and how to get it in time.
0.9 mg/kg IV; not to exceed 90 mg total dose; administer 10% of the total dose as an initial IV bolus over 1 minute and the remainder infused...
Learn how NINDS played a major role in the development of tPA, the first FDA-approved treatment for acute ischemic stroke. See the timeline of clinical trials, discoveries, and outcomes of tPA, a clot-dissolving medicine given through an IV.
Feb 20, 2023 · This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, toxicity, and monitoring, of tPA agents so providers can direct patient therapy where they are indicated as part of the interprofessional team.
- Talha N. Jilani, Abdul H. Siddiqui
- 2023/02/20
- 2019
Jun 30, 2023 · Learn about the administration and selection of intravenous thrombolytic therapy for patients with acute ischemic stroke. This article reviews the evidence, indications, contraindications, and complications of this reperfusion therapy option.
Jul 4, 2023 · The sooner the patient receives tPA; the better are the outcomes. Maximum recommended dose is 90mg. Patients less than or equal to 100 kg load with 0.09 mg/kg (10% of 0.9 mg/kg dose) as an IV bolus over 1 minute, followed by 0.81 mg/kg (90% of 0.9 mg/kg dose) as a continuous infusion over 60 minutes.
Apr 30, 2024 · An IV injection of recombinant tissue plasminogen activator (TPA) is the gold standard treatment for ischemic stroke. The two types of TPA are alteplase (Activase) and tenecteplase (TNKase). An injection of TPA is usually given through a vein in the arm within the first three hours.
