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1. publications.aap.org › pediatrics › articleClinical Practice Guideline: Evaluation and Management of ...

   publications.aap.org › pediatrics › article

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   Aug 1, 2021 · This guideline addresses the evaluation and management of well-appearing, term infants, 8 to 60 days of age, with fever ≥38.0°C. Exclusions are noted. After a commissioned evidence-based review by the Agency for Healthcare Research and Quality, an additional extensive and ongoing review of the literature, and supplemental data from published, peer-reviewed studies provided by active ...

2. publications.aap.org › pediatrics › articleManagement of Neonates Born at ≤34 6/7 Weeks’ Gestation With ...

   publications.aap.org › pediatrics › article

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   Dec 1, 2018 · Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that ...

   • Author: Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn

   • Publish Year: 2018

3. People also ask

   How is early onset neonatal sepsis treated?

   • The only intervention proven to decrease the incidence of early-onset neonatal sepsis is maternal treatment with intrapartum intravenous antimicrobial agents for the prevention of GBS infections. 93 Adequate prophylaxis is defined as penicillin (the preferred agent), ampicillin, or cefazolin given for ≥4 hours before delivery.

   Management of Neonates With Suspected or Proven Early-Onset Bacter…

   publications.aap.org/pediatrics/article/129/5/1006/73781/Management-of-Neonates-With-Suspected-or-Proven

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   How common is early onset neonatal sepsis?

   • Pediatrics (2012) 129 (5): 1006–1015. With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population.

   Management of Neonates With Suspected or Proven Early-Onset Bacter…

   publications.aap.org/pediatrics/article/129/5/1006/73781/Management-of-Neonates-With-Suspected-or-Proven

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   Are there alternative approaches to assessing infants with suspected sepsis?

   • The AAP guideline offers three alternative strategies for the management of infants with suspected sepsis: categorical risk assessment, multivariate risk assessment (sepsis calculator) and risk assessment based on the infant’s clinical condition using serial observations.12 Each of these approaches has strengths and limitations.

   What s new in the management of neonatal early-onset sepsis?

   fn.bmj.com/content/fetalneonatal/108/1/10.full.pdf

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4. fn.bmj.com › content › fetalneonatalWhat s new in the management of neonatal early-onset sepsis?

   fn.bmj.com › content › fetalneonatal

   a single CRP value for proven sepsis was 64% (95% CI 53 to. 59) with a positive predictive value of only 14% (95% CI 11 to. 17).45 However, if serial CRP values remain normal, there is a low likelihood of infection with a negative predictive value of nearly 100%46 The 2021 NICE guidelines recommend use of.