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Aug 1, 2021 · This guideline addresses the evaluation and management of well-appearing, term infants, 8 to 60 days of age, with fever ≥38.0°C. Exclusions are noted. After a commissioned evidence-based review by the Agency for Healthcare Research and Quality, an additional extensive and ongoing review of the literature, and supplemental data from published, peer-reviewed studies provided by active ...
Dec 1, 2018 · Early-onset sepsis (EOS) is a serious and potentially fatal complication of birth. Assessing term and late-preterm newborn infants for risk of EOS is one of the most common clinical tasks conducted by pediatric providers. 1 As the use of preventive intrapartum antibiotic therapies has increased and the incidence of EOS has decreased, physicians are challenged to identify those newborn infants ...
- Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn
- 2018
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May 1, 2012 · With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal ...
- Richard A. Polin, Newborn
- 2012
Jan 1, 2023 · Abstract. Early-onset sepsis can cause significant morbidity and mortality in newborn infants. Risk factors for sepsis include birth to mothers with inadequately treated maternal group B Streptococcus colonization, intra-amniotic infection, maternal temperature greater than 100.4°F (>38°C), rupture of membranes greater than 18 hours, and preterm labor. The organisms that most commonly cause ...
Dec 1, 2018 · Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that ...
- Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn
- 2018
Feb 23, 2022 · Purpose/Objectives: Neonatal early onset sepsis (EOS) is an invasive bacterial infection of the blood or cerebrospinal fluid occurring in the first week of life. Signs of EOS are nonspecific and therefore difficult to diagnose clinically. EOS is associated with significant morbidity and mortality. In an attempt to avoid missing a diagnosis of EOS, providers may obtain serial complete blood ...
Jan 13, 2022 · Address correspondence to Amy E. O’Connell, MD, PhD, Division of Newborn Medicine, Boston Children’s Hospital, Enders 9, 300 Longwood Ave, Boston, MA 02130. E-mail: amy.oconnell@childrens.harvard.edu. Pediatrics (2022) 149 (2): e2021054221. In this issue of Pediatrics, Flannery et al 1 consider whether infants with a clear low risk of ...
