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Aug 1, 2021 · This guideline addresses the evaluation and management of well-appearing, term infants, 8 to 60 days of age, with fever ≥38.0°C. Exclusions are noted. After a commissioned evidence-based review by the Agency for Healthcare Research and Quality, an additional extensive and ongoing review of the literature, and supplemental data from published, peer-reviewed studies provided by active ...
Dec 1, 2018 · The incidence of neonatal early-onset sepsis (EOS) has declined substantially over the last 2 decades, primarily because of the implementation of evidence-based intrapartum antimicrobial therapy. However, EOS remains a serious and potentially fatal illness. Laboratory tests alone are neither sensitive nor specific enough to guide EOS management decisions. Maternal and infant clinical ...
- Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn
- 2018
Dec 1, 2018 · Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that ...
- Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn
- 2018
Dec 12, 2023 · Sepsis and septic shock are major causes of morbidity, mortality, and health care costs for children worldwide, including >3 million deaths annually and, among survivors, risk for new or worsening functional impairments, including reduced quality of life, new respiratory, nutritional, or technological assistance, and recurrent severe infections. Advances in understanding sepsis pathophysiology ...
Sep 29, 2022 · Neonatal sepsis refers to an infection involving the bloodstream in newborn infants less than 28 days old. It remains a leading cause of morbidity and mortality among neonates, especially in middle and lower-income countries [1]. Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis ...
- Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
- 2022/09/29
Feb 23, 2022 · Purpose/Objectives: Neonatal early onset sepsis (EOS) is an invasive bacterial infection of the blood or cerebrospinal fluid occurring in the first week of life. Signs of EOS are nonspecific and therefore difficult to diagnose clinically. EOS is associated with significant morbidity and mortality. In an attempt to avoid missing a diagnosis of EOS, providers may obtain serial complete blood ...
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Mar 29, 2015 · Introduction. Neonatal infections continue to cause morbidity and mortality in infants. Among approximately 400,000 infants followed nationally, the incidence rates of early-onset sepsis (EOS) infection within 3 days of life were 0.98 cases per 1000 live births. 1 More than two-thirds of the frequently isolated organisms were associated with group B streptococcus (GBS) (43%) and Escherichia ...
