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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections. Serotonin generation comes from L-tryptophan via a two-step process catalyzed by tryptophan hydroxylase and L-aromatic amino ...
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
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Connections of the raphe nuclei with the forebrain develop at 7–8 weeks (stages 21–23), probably via the central tegmental tract, and the nuclei come to be situated within the septum medullae (stage 23). Two distinct raphe nuclei at 8 weeks (stage 23) have been reconstructed (O'Rahilly and Müller, 1999a, figures 23-27).
The nucleus raphe pallidus has also been known to mediate the tachycardia response, an extremely high heart rate known to be incited by emotional or psychological stress. Microinjections of a GABA-a antagonist into the nucleus raphe pallidus, induces an increased heart rate. Conversely, microinjections of muscimol, a GABA-a agonist, inhibit ...
The raphe nuclei is a cluster of neurons that are housed in the pons and medulla within the hindbrain . Functionally, it is the primary site of serotonin production [ 5 ]. Serotonin is an essential neurotransmitter of the central nervous system that is found throughout brain regions that play a vital role in regulating aspects of eating, sleep ...
May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
The raphe magnus nucleus (RMg) is located in the caudal pons and the most rostral portion of the medulla ( Figure 11.3). It is restricted to the midline, overlying the medial lemniscus where its fibers are shifting from their ventromedial to a more lateral position as they enter the pons. The RMg is found at the same level as the facial nucleus.
