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  3. Does Your Dog's Current Medication Offer as Much Protection as SIMPARICA TRIO®? Rethink Your Dog's Protection with SIMPARICA TRIO®. Talk With Your Vet

  4. NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets). NexGard® PLUS chews protect puppies as young as 8 weeks of age weighing 4 lbs or more.

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      • Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate.
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  2. Simparica Trio is a monthly chewable that prevents heartworm disease, ticks, fleas, and intestinal parasites in dogs. Learn about the product, its benefits, and its safety information from Zoetis Petcare.

  3. Simparica Trio is a chewable tablet that protects dogs against heartworm, ticks, fleas, roundworms and hookworms in one dose. Shop by weight and save 40% on first autoship prescription item at Chewy.com.

  4. Apr 11, 2024 · Simparica Trio is a chewable tablet that protects dogs from heartworms, fleas, ticks, and intestinal parasites. Learn about its side effects, safety, dosage, cost, and interactions with other medications.

  5. Simparica Trio is a monthly chewable that prevents heartworm disease, ticks, fleas, roundworms and hookworms in dogs. It is the first and only product that combines sarolaner, moxidectin and pyrantel in one simple-to-give chewable.

    • Description
    • Simparica Trio Indications
    • Simparica Trio Dosage and Administration
    • Warnings
    • Precautions
    • Adverse Reactions
    • Contact Information
    • Clinical Pharmacology
    • Mode of Action
    • Heartworm Prevention
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    SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Sarolaner is a mem...

    SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adu...

    SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dosage Schedule SIMPARICA TRIO can be offered to the dog with or without food. Care should be taken to ensure that the dog consumes the complete dos...

    Not for use in humans. Keep this and all drugs out of reach of children. Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.

    Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a histor...

    In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. The study included a total of 410 dogs treated once monthly for 11 treatments (272 treated with SIMPARICA TRIO and 138 treated with an active control). Over the 330-day study period, all observations of potential adverse react...

    For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

    Following oral administration of SIMPARICA TRIO in Beagle dogs (13 to 15 months of age at the time of initial dosing), sarolaner and moxidectin were rapidly and well-absorbed. Following a single oral dose of SIMPARICA TRIO (sarolaner dose of 1.2 mg/kg), the sarolaner mean maximum plasma concentration (Cmax) was 523 ng/mL with a mean time to maximum...

    SIMPARICA TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in...

    In two well-controlled laboratory studies, a single oral dose of SIMPARICA TRIO was 100% effective in preventing the development of adult D. immitisin dogs inoculated with infective larvae 30 days before treatment. In a well-controlled US field study consisting of 246 dogs administered SIMPARICA TRIO and 119 administered an active control, no dogs ...

    Simparica TRIO is a chewable tablet that prevents heartworm disease, treats and controls flea and tick infestations, and treats roundworm and hookworm infections in dogs. Learn about its indications, dosage, administration, and safety information.

    • 888-963-8471
    • www.zoetis.com
    • 269-359-4414
  6. Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Simparica Trio does the work of two or three parasiticides in a single chewable by combining three proven ingredients.

  7. Simparica Trio is Designed for Defense. It’s the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against heartworm disease, ticks and fleas, and intestinal worms. Easy to Administer. Nine out of ten dogs voluntarily ate the chewable. 5. Demonstrated Safe for Dogs.

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  2. Does Your Dog's Current Medication Offer as Much Protection as SIMPARICA TRIO®? Rethink Your Dog's Protection with SIMPARICA TRIO®. Talk With Your Vet

  3. NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets). NexGard® PLUS chews protect puppies as young as 8 weeks of age weighing 4 lbs or more.

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