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Tau is a negative regulator of mRNA translation in Drosophila, mouse, and human brains, through its binding to ribosomes, which results in impaired ribosomal function, reduction of protein synthesis and altered synaptic function.
Apr 6, 2017 · Recent advances in our understanding of the multiple functions and different locations of tau inside and outside neurons have revealed novel insights into its importance in a diverse range of molecular pathways including cell signalling, synaptic plasticity, and regulation of genomic stability.
Dec 3, 2015 · In this Review, Wang and Mandelkow describe the structure, expression and post-translational modifications of tau, and the functions of this protein in health and in disease.
Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal physiological conditions. However, in certain pathological situations, tau protein may undergo modifications, mainly through phosphorylation, that can result in the generation of aberrant aggregates that are toxic to neurons.
Mar 19, 2021 · Illuminating compartment-specific functions of tau would significantly advance our knowledge of its normal physiology and provide critical clues on the pathobiological roles played by this protein. Scaffold proteins are important regulators of many intracellular signaling pathways.
Aug 6, 2019 · Tau is a stabilizing MT associated protein, whose functions are mainly regulated by phosphorylation. A disruption of the MT network, which might be caused by Tau loss of function, is observed in a group of related diseases called tauopathies, which includes Alzheimer’s disease (AD).
Aug 15, 2012 · This paper takes you through the under-reported part of the tau story; it summarizes the consequences for tau loss of function and its possible role in neurodegeneration. The authors thoroughly reviewed the different tau knockout models and addressed the pathophysiology of various tau models.
The diversity of tau binding partners coupled with the discovery of tau other than axonal compartments such as nucleus, dendrites, and synapses have led to the proposal of novel functions for tau in roles such as nuclear stability, cell signaling, transcriptional processing, and protein synthesis.
This paper takes you through the under-reported part of the tau story; it summarizes the consequences for tau loss of function and its possible role in neurodegeneration. The authors thoroughly reviewed the different tau knockout models and addressed the pathophysiology of various tau models.
Much evidence has been accumulated pointing to the contribution of tau to AD pathology by two mechanisms: loss of function (such as stabilization of microtubules) as well as gain of toxic function (aggregation and deposition as neurofibrillary tangles).
