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  1. Valneva and Pfizer have developed a Lyme disease vaccine candidate, VLA15, that is currently in Phase 3 human trials. VLA15 is a multivalent, protein subunit vaccine that targets the outer surface protein A (OspA) of Borrelia. This vaccine is designed to protect people against North American and European strains of the Lyme disease bacterium.

    • A Fraught History of Lyme Vaccines
    • A New Type of Prevention Shot
    • A More Traditional Vaccine Could Be Available Next Summer
    • Other Ways to Prevent Tick-Borne Illness

    Twenty-five years ago, a vaccine called LYMErix debuted. It was shown to be 76% effective at preventing Lyme disease. But by 2002, vaccine manufacturer SmithKlineBeecham pulled it from the market due to poor sales. The company faced a class action lawsuit alleging that LYMErix caused arthritis in vaccine recipients. Multiple Food and Drug Administr...

    Most vaccines work by introducing a version of the bacteria or virus into the body. These inactive antigens trigger the immune system to create antibodies that can attack the real pathogen, should it ever enter the body. A group of researchers at MassBiologics are taking a different approach—a prophylaxisshot that delivers monoclonal antibodies dir...

    The vaccine that is closest to the finish line is being developed by Pfizer and Valneva. VLA15, as it’s called, is a three-dose vaccine that trains the immune system to create antibodies that handicap Borreliain the tick’s gut, just as Lyme PrEP does. According to the companies, phase 2 clinical trials showed the vaccine was safe in people as young...

    While Lyme is the most common of the tick-borne diseases, it’s not the only one, said Neeta Pardanani Connally, MSPH, PhD, professor of biology and Director of the Tickborne Disease Prevention Laboratory at Western Connecticut State University. Ticks in the U.S. can carry pathogens that cause 16 diseases, including Powassan virus disease, ehrlichio...

  2. Aug 9, 2022 · If it were to gain regulators' approval, it would become the only Lyme disease vaccine available for humans in the U.S. But it's expected to take years for the potential vaccine to reach...

  3. Jun 17, 2021 · Currently, there is no human vaccine for Lyme diseaseeven though more than two decades ago, people could get a safe and effective preventative shot similar to Fawn’s. Now, thanks to potent...

  4. Sep 19, 2023 · September 19, 2023. PHILADELPHIA— An experimental mRNA vaccine provides protection in preclinical animal models against infection from Borrelia burgdorferi, the bacteria that causes Lyme disease, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

  5. Sep 22, 2022 · AAMCNews. Lyme disease is on the rise. Why is there still no vaccine? Two decades after a vaccine was withdrawn, scientists are producing new medicines to fend off a disease that experts estimate afflicts nearly half a million people each year. By Patrick Boyle, Senior Staff Writer. Sept. 22, 2022. Imagine trying to medicate a bug.

  6. Apr 29, 2021 · As of October 2022, VLA15 was the sole active vaccine candidate program in clinical development aimed at preventing the spread of the disease. 11 Preclinical experiments in animal models found that the vaccine candidate was able to effectively prevent transmission of North American and European Borrelia strains from infected Ixodes ticks. 11 If ...

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