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Feb 23, 2024 · Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this process is increasingly recognized as a critical ...
Nov 16, 2017 · To deplete a protein, researchers have two main techniques at hand: genome editing by CRISPR/Cas, and RNA interference (RNAi). By targeting a cell's DNA or RNA, respectively, they efficiently...
Oct 28, 2021 · Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.
Apr 21, 2020 · Interestingly, this can be used either to block mature protein expression or to correct aberrant splicing thereby restoring the protein function. Furthermore, oligonucleotides can result in steric hindrance of translation by preventing ribosome binding when targeted near the translation initiation codon (Chery, 2016 ; Goyal and Narayanaswami ...
- Nihay Laham-Karam, Gaspar P. Pinto, Antti Poso, Antti Poso, Piia Kokkonen
- 10.3389/fchem.2020.00276
- 2020
- Front Chem. 2020; 8: 276.
Multiple polymerases can transcribe a single bacterial gene while numerous ribosomes concurrently translate the mRNA transcripts into polypeptides. In this way, a specific protein can rapidly- within minutes- reach a high concentration in the bacterial cell.
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Jan 1, 2021 · Deregulation of protein synthesis may be involved in multiple aspects of cancer, such as gene expression, signal transduction and drive specific cell biological responses, resulting in promoting cancer growth, invasion and metastasis. Study the molecular mechanisms about translational control may help us to find more effective anti-cancer drugs ...
Mar 20, 2014 · RNA encodes the proteins that play a key role in cellular reproduction, but the manner in which cells regulate its removal once these proteins are synthesized remains a mystery. One piece of this ...
