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We discuss the immunological events elicited during a DENV infection and identify candidate cytokines that may play a key role in the severe manifestations of dengue and possible interventions. Keywords: Dengue, Dengue hemorrhagic fever, plasma leakage, innate immunity, adaptive immunity, cytokines
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Immunological events in DENV infection. DENV is introduced...
- Distinct Activation Phenotype of a Highly Conserved Novel HLA-B57-restricted Epitope During Dengue Virus Infection
Study subjects and blood samples. The study design for...
- Increased Frequencies of CD4+CD25high Regulatory T Cells in Acute Dengue Infection
Identification of CD4 + CD25 high T reg cells. Patients'...
- Dengue Virus Inoculation to Human Skin Explants
Dengue virus (DV) infections are serious causes of morbidity...
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Jan 6, 2024 · Our findings reveal a distinct cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4 and decreased IL-12, MIP-1β) on the third day after symptom onset is predictive of severe dengue in secondary dengue infection.
- 10.1016/j.virusres.2023.199306
- 2024/03
- Virus Res. 2024 Mar; 341: 199306.
- Cytokine Storm Symptoms
- What's Happening in The Body
- Cytokine Storm and Covid-19
- Causes of Cytokine Storm Syndrome
- Cytokine Storm Syndrome Diagnosis
- Cytokine Storm Treatment
- Summary
- A Word from Verywell
Cytokine storm symptoms are varied and might include: 1. Fevers and chills 2. Fatigue 3. Swelling of extremities 4. Nausea and vomiting 5. Muscle and joint aches 6. Headache 7. Rash 8. Cough 9. Shortness of breath 10. Rapid breathing 11. Seizures 12. Tremor 13. Difficulty coordinating movements 14. Confusion and hallucinations 15. Lethargy and poor...
Cytokine storm is a cascade of exaggerated immune responses that can cause serious problems. It is not considered a disease in itself, but rather a serious medical issue that can happen because of several underlying issues. It is also sometimes called cytokine release syndrome, CRS, or just cytokine storm. The immune system has many different compo...
In people experiencing cytokine storm syndrome, certain cytokines are present in the blood at higher-than-normal amounts. In COVID-19, elevations in several inflammatory cytokines seem to be involved in the development of acute respiratory distress syndrome, the leading cause of death in people dealing with COVID-19 illness. Most people with COVID-...
Scientists are still working to understand the complex web of causes that can cause cytokine storm to start. Several different types of underlying health issues may cause it.
Doctors consider the underlying medical condition when diagnosing cytokine storm. This underlying problem might be already known, or it may require its own diagnosis. A person might need to be diagnosed with: 1. A genetic disorder 2. An autoimmune condition 3. An infectious disease, like COVID-19 Depending on the situation, this might require vario...
Supportive care is a critical part of treatment for cytokine storm. Sometimes an individual is experiencing severe symptoms, like difficulty breathing. They may need care in an intensive care unit. This might include support such as the following: 1. Intensive monitoring of vital signs 2. Ventilatorysupport 3. Fluids given intravenously 4. Manageme...
Cytokine storm happens when the immune system produces too many inflammatory signals. This can can cause serious symptoms that in some cases can lead to organ failure and death. Symptoms of cytokine storm can include confusion, shortness of breath, lethargy, and more. It is treated with supportive care, which may include fluids, breathing assistanc...
Cytokine storm syndrome is a problem of immune system dysregulation that may cause life-threatening symptoms. It’s scary and frustrating to learn that someone you care about is battling such a problem. However, know that you aren’t alone. Medical professionals will do everything possible to make sure your loved one receives the best possible care.
Oct 3, 2022 · Various pathogens and malignant and autoimmune diseases as well as genetic changes, but also iatrogenic interventions, can disturb this equilibrium so that an excessive release of cytokines can occur. In its severe (albeit rare) form, this is referred to as cytokine storm.
- Dominik Jarczak, Axel Nierhaus
- Int J Mol Sci. 2022 Oct; 23(19): 11740.
- 10.3390/ijms231911740
- 2022/10
Dec 2, 2020 · In severe cases of cytokine storm, renal failure, acute liver injury or cholestasis, and a stress-related or takotsubo-like cardiomyopathy can also develop. 9 The...
Oct 3, 2022 · In its severe (albeit rare) form, this is referred to as cytokine storm. As a result, positive feedback mechanisms and self-sustained activation of immune cells occur. The resulting hyperinflammation can lead to a life-threatening condition.
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Nov 25, 2015 · Dengue virus causes a range of diseases with a small proportion of infected patients developing severe plasma leakage that leads to dengue shock syndrome, organ impairment and bleeding....
