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      • LOS is primarily attributed to nosocomial or horizontal pathogen acquisition, and exposures to hospital or community environments. Pathogen exposure may occur due to contamination or colonization of indwelling invasive medical devices, contact with care providers, and/or other environmental sources and surfaces.
      www.ncbi.nlm.nih.gov › pmc › articles

      Updates in Late-Onset Sepsis: Risk Assessment, Therapy and ...

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  3. www.ncbi.nlm.nih.gov › pmc › articlesUpdates in Late-Onset Sepsis: Risk Assessment, Therapy and...

    Nov 11, 2022 · Neonatal late-onset sepsis (LOS) remains a significant cause of morbidity and mortality in the NICU, particularly among extremely preterm and/or chronically ill infants.

  4. publications.aap.org › neoreviews › articleUpdates in Late-Onset Sepsis: Risk Assessment, Therapy, and ...

    Nov 1, 2022 · Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  5. www.ncbi.nlm.nih.gov › pmc › articlesRisk Factors and Prevention of Late Onset Sepsis in Premature ...

    Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters.

    • L. Corbin Downey, P. Brian Smith, Daniel K. Benjamin
    • 10.1016/j.earlhumdev.2010.01.012
    • 2010
    • 2010/07

  6. www.nature.com › articles › s41372/019/0577-5Standardizing the approach to late onset sepsis in neonates ...

    Jan 6, 2020 · Late onset sepsis (LOS; i.e., sepsis onset >72 h after birth) remains a leading cause of neonatal mortality . It often presents with nonspecific signs of illness (e.g., temperature...

    • V Lamba, S D'souza, C Carafa, A Zepf, C L Bassel, M Gutierrez, M Balakrishnan
    • 2020

  7. fn.bmj.com › content › 100Late-onset neonatal sepsis: recent developments | ADC Fetal ...

    Major causative pathogens of neonatal late-onset sepsis and their incidence by geographical areas. Gram-negative bacilli responsible for neonatal LOS mainly include Escherichia coli, Klebsiella spp., Enterobacter spp. and Pseudomonas spp. ( figure 1 ).

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  9. fn.bmj.com › content › fetalneonatalReview Late-onset neonatal sepsis: recent developments

    Epidemiological data on very low birth weight infants shows that the predominant pathogens of neonatal LOS are coagulase-negative staphylococci, followed by Gram-negative bacilli and fungi.

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