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    • Nosocomial or horizontal pathogen acquisition

      • LOS is primarily attributed to nosocomial or horizontal pathogen acquisition, and exposures to hospital or community environments. Pathogen exposure may occur due to contamination or colonization of indwelling invasive medical devices, contact with care providers, and/or other environmental sources and surfaces.
      www.ncbi.nlm.nih.gov › pmc › articles

      Updates in Late-Onset Sepsis: Risk Assessment, Therapy and ...

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  3. www.ncbi.nlm.nih.gov › pmc › articlesUpdates in Late-Onset Sepsis: Risk Assessment, Therapy and...

    Nov 11, 2022 · Neonatal late-onset sepsis (LOS) remains a significant cause of morbidity and mortality in the NICU, particularly among extremely preterm and/or chronically ill infants. Early recognition and diagnosis of LOS is challenging due to often non-specific presenting features and limited diagnostic efficiency of commonly used biomarkers.

  4. publications.aap.org › neoreviews › articleUpdates in Late-Onset Sepsis: Risk Assessment, Therapy, and ...

    Nov 1, 2022 · Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  5. www.ncbi.nlm.nih.gov › books › NBK531478Neonatal Sepsis - StatPearls - NCBI Bookshelf

    Sep 29, 2022 · Neonatal sepsis is divided into 2 groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis in neonates at or before 72 hours of life (some experts use 7 days), and LOS is defined as sepsis occurring at or after 72 hours of life [2].

    • Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
    • 2022/09/29

  6. www.ncbi.nlm.nih.gov › pmc › articlesRisk Factors and Prevention of Late Onset Sepsis in Premature ...

    Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters.

    • L. Corbin Downey, P. Brian Smith, Daniel K. Benjamin
    • 10.1016/j.earlhumdev.2010.01.012
    • 2010
    • 2010/07

  7. www.bmj.com › content › 371Neonatal sepsis | The BMJ

    Oct 1, 2020 · Late onset sepsis (LOS), in contrast, results from postnatal environmental exposure to pathogenic bacteria. 4 Disagreement exists in the literature about the cut off point between EOS and LOS; some sources use 72 hours, some use seven days. 5 6 7 Incidence of LOS is higher in premature infants. 8 The composition of the newborn microbiome is high...

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  9. www.msdmanuals.com › neonatal-sepsisNeonatal Sepsis - Pediatrics - MSD Manual Professional Edition

    Late-onset neonatal sepsis is usually acquired from the environment ( see Neonatal Hospital-Acquired Infection). Staphylococci account for 30 to 60% of late-onset cases and are most frequently due to intravascular devices (particularly central vascular catheters).

  10. www.cdc.gov › nhsn › pdfsLate Onset Sepsis / Meningitis Event - Centers for Disease ...

    Synonym: event date. LOS/MEN Window Period: The 5-day period around the positive common commensal blood or CSF specimen that includes the 2 days before, the day of, and the 2 days after the LOS/MEN event date.

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