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  1. Nov 11, 2022 · Abstract. Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality within the neonatal intensive care unit (NICU) and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

    • Sarah A. Coggins, Kirsten Glaser
    • 2022/11/11
    • 10.1542/neo.23-10-e738
  2. Nov 1, 2022 · Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration. Preterm infants—born at ever-decreasing gestational ages—are at particularly high risk for life ...

  3. Abstract. Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters. Methods studied to prevent late-onset sepsis include early feedings, immune globulin ...

    • L. Corbin Downey, P. Brian Smith, Daniel K. Benjamin
    • 10.1016/j.earlhumdev.2010.01.012
    • 2010
    • 2010/07
  4. Sep 29, 2022 · Neonatal sepsis refers to an infection involving the bloodstream in newborn infants less than 28 days old. It remains a leading cause of morbidity and mortality among neonates, especially in middle and lower-income countries [1]. Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis ...

    • Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
    • 2022/09/29
  5. The incidence of neonatal late-onset sepsis (LOS) is inversely related to the degree of maturity and varies geographically from 0.61% to 14.2% among hospitalised newborns. Epidemiological data on very low birth weight infants shows that the predominant pathogens of neonatal LOS are coagulase-negative staphylococci, followed by Gram-negative bacilli and fungi. Due to the difficulties in a ...

    • Ying Dong, Christian P Speer
    • 2015
  6. Oct 1, 2020 · Late onset sepsis (LOS), in contrast, results from postnatal environmental exposure to pathogenic bacteria.4 Disagreement exists in the literature about the cut off point between EOS and LOS; some sources use 72 hours, some use seven days.5 6 7 Incidence of LOS is higher in premature infants.8 The composition of the newborn microbiome is highly ...

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  8. Apr 18, 2024 · 6 (IL-6) is a promising marker for neonatal sepsis. We aimed to test the accuracy of IL-6 in neonates after 72 h of life in case of late onset sepsis (LOS). We searched for studies regarding IL-6 accuracy for the diagnosis of LOS between 1990 and 2020 using the PubMed database.

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    Elevate care in critical conditions with our SIRS, Sepsis, and Septic Shock Calculator. Navigate sepsis diagnosis with the SIRS, Sepsis, and Septic Shock Criteria Calculator.

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