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- Princeton geneticist and Howard Hughes Medical Institute Investigator Bonnie Bassler helped lead a revolution in the way scientists think about bacteria. Her lab's work on quorum sensing—essentially how bacteria "talk" with one another and act as groups—has spawned a flurry of medical research and may one day bring us a new class of drugs.
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Bonnie Lynn Bassler (born 1962) is an American molecular biologist; the Squibb Professor in Molecular Biology and chair of the Department of Molecular Biology at Princeton University; and a Howard Hughes Medical Institute Investigator.
Bassler and her students helped turn a harmless, bioluminescent bacterium into a star of scientific research—a model organism holding lessons about how all bacteria communicate.
Jan 1, 2007 · Bassler and her students helped turn a harmless, bioluminescent bacterium into a star of scientific research—a model organism holding lessons about how all bacteria communicate.
Oct 24, 2013 · She elucidated the chemical language that bacteria use to communicate through a process called quorum sensing that allows bacteria to count their numbers, determine when they’ve reached a critical mass, and then change their behavior in unison to result in virulence or even bioluminescence.
- Ushma S. Neill
- 10.1172/JCI75027
- 2014
- J Clin Invest. 2014 Apr 1; 124(4): 1421-1422.
Bonnie Bassler discovered that bacteria "talk" to each other, using a chemical language that lets them coordinate defense and mount attacks. The find has stunning implications for medicine, industry -- and our understanding of ourselves.
Bonnie L. Bassler is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is a Howard Hughes Medical Institute Investigator and the Squibb Professor of Molecular Biology at Princeton University.
By contrast, in biochemistry and molecular biology courses I could use logic to solve puzzles, and I was thrilled by the wondrous, miniature building blocks that made life possible: DNA, RNA, and proteins. I changed my major to biochemistry and my Grade Point Average soared.
