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Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits Common causes are infections, neoplasms, and connective tissue disorders.
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Introduction. The definition of pyrexia of unknown origin (PUO) dates back to 1961; it was described as a persistent fever above 38.3°C (100°F) that evades diagnosis for at least 3 weeks, including 1 week of investigation in hospital. 1 This definition has evolved with faster and more accurate diagnostic techniques and changing models of care, and a week of hospitalisation is no longer ...
- Cristina Fernandez, Nicholas Beeching
- 10.7861/clinmedicine.18-2-170
- 2018
- Clin Med (Lond). 2018 Apr; 18(2): 170-174.
Sep 16, 2016 · Pyrexia of unknown origin (PUO) is a syndrome that has long tested the skills of physicians to achieve a diagnosis in affected patients. By definition, patients included in this syndrome will be more difficult to diagnose as they have already resisted classification during baseline investigations.
- Robyn W Beresford, Iain B Gosbell, Iain B Gosbell
- 2016
Sep 4, 2023 · Fever, or pyrexia, is the elevation of an individual's core body temperature above a 'set-point' regulated by the body's thermoregulatory center in the hypothalamus.
- 2023/09/04
Oct 3, 2016 · Whilst a great deal of progress has been made regarding optimal temperature management in recent years, further studies will be needed to determine which patients would benefit the most from control of pyrexia and by which means this should be implemented. This narrative review is part of a series on the pathophysiology and management of pyrexia.
- James F. Doyle, Frédérique Schortgen
- 10.1186/s13054-016-1467-2
- 2016
- Crit Care. 2016; 20: 303.
Sep 1, 2016 · In the meantime, using existing literature, we propose an approach to identifying the aetiology of pyrexia in critically ill adults. Elevation in core body temperature is one of the most frequently detected abnormal signs in patients admitted to adult ICUs, and is associated with increased mortality in select populations of critically ill patients.
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Aug 18, 2011 · 9.1 Background. General review definition divides PUO as classical, nosocomial, HIV-related and immunosuppression-related [].For HIV infection, pyrexia of unknown origin (PUO) identifies a pattern of fever with temperature higher than 38.3 °C on several occasions over more than 4 weeks for outpatients, or more than 3 days duration in hospital, in which the diagnosis remains uncertain after an ...
