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Sep 4, 2023 · Fever, or pyrexia, is the elevation of an individual's core body temperature above a 'set-point' regulated by the body's thermoregulatory center in the hypothalamus. This increase in the body's 'set-point' temperature is often due to a physiological process brought about by infectious causes or non-infectious causes such as inflammation, malignancy, or autoimmune processes. These processes ...
- 2023/09/04
Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits Common causes are infections, neoplasms, and connective tissue disorders A thorough history and physical examination, along with basic investigations will usually
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What is pyrexia physiology?
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- Hyperthermia Syndromes
- Pyrexia Due to Infectious Aetiologies
- Pyrexia Due to Noninfectious Aetiologies
- Incidence of Pyrexia and Aetiologies
The hyperthermia syndromes, generally characterized by severely elevated body temperature, include: environmental hyperthermia including heatstroke ; drug-induced hyperthermia, including malignant hyperthermia , neuroleptic malignant syndrome , and serotonin syndrome ; and endocrine causes including thyrotoxicosis, pheochromocytoma, and adrenal cri...
Many episodes of pyrexia are due to infections, and can be broadly divided according to whether they are community onset or hospital onset, with hospital-onset infections manifesting 48 hours or more after admission to hospital . Whether community onset or hospital onset, the most common source of infection in immunocompetent critically ill patient...
Noninfectious diagnoses are also common causes of pyrexia in adult ICUs, especially among patients with an acute neurological condition . Unless there are obvious signs and symptoms of the particular noninfectious problem, such as an exanthem in the context of a drug reaction or asymmetric leg edema in the context of deep vein thrombosis, these dia...
The incidence of pyrexia among critically ill adults depends on the defining temperature threshold and the population studied (Table 1). A systematic review of nine observational studies in patients admitted to the ICU without an acute neurological condition found that the fever incidence varied between 26 and 88 % . The largest studies were from B...
- Daniel J. Niven, Daniel J. Niven, Kevin B. Laupland
- 2016
Pyrexia: An update on importance in clinical practice. Pyrexic patients are usually attended with some scepticism by anaesthesiologists. Main reasons are the absence of comprehensible guidelines pertaining to anaesthesia in such patients and the presence of innumerable aetiologies of pyrexia. This article has tried to fill the existing void in ...
- Ragi Jain, Deepesh Saxena
- 10.4103/0019-5049.154996
- 2015
- Indian J Anaesth. 2015 Apr; 59(4): 207-211.
Oct 3, 2016 · The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia. The host response to pyrexia varies, however, according to the disease profile and severity and, as such, the management of pyrexia should differ; for example, temperature control is safe and effective in septic shock but ...
- James F. Doyle, Frédérique Schortgen
- 2016
Oct 15, 2010 · Few clinical problems generate such a wide differential diagnosis as pyrexia (fever) of unknown origin. The initial definition proposed by Petersdorf and Beeson in 1961,1 later revised, is “a fever of 38.3°C (101°F) or more lasting for at least three weeks for which no cause can be identified after three days of investigation in hospital or after three or more outpatient visits.”2 3 4 ...
Jan 8, 2010 · Pyrexia: is an elevation of body temperature above the normal daily variation (NICE, 2007). Core temperature >37.5ºC is considered a pyrexia (Leach, 2009). Hyperpyrexia: temperature >40ºC (Dougherty and Lister, 2008). Fever: an abnormal rise in body temperature, usually accompanied by shivering, headache and, if severe, delirium.
