Yahoo Web Search

Sign In

Search results

  1. www.ncbi.nlm.nih.gov › pmc › articlesConflicting theories on addiction aetiology and the strengths and...

    Sep 6, 2023 · Theories conceptualizing addiction through the three-stage brain disease model contest other theories that substance use disorder is of behavioural or genetic origin. The reverberations of this lack of consensus are noticeable throughout addiction research and within the foundations of disease modelling.

    • Megan R. Greener, Sarah J. Storr
    • Front Mol Neurosci. 2023; 16: 1166852.
    • 10.3389/fnmol.2023.1166852
    • 2023

  2. www.nature.com › articles › s41583/020/0289-zThe transition to compulsion in addiction | Nature Reviews ...

    Mar 30, 2020 · Abstract. Compulsion is a cardinal symptom of drug addiction (severe substance use disorder). However, compulsion is observed in only a small proportion of individuals who repeatedly seek and use ...

    • Christian Lüscher, Christian Lüscher, Trevor W. Robbins, Barry J. Everitt
    • 2020

  3. People also ask

  4. www.ncbi.nlm.nih.gov › pmc › articlesAddiction as a brain disease revised: why it still matters ...

    Feb 22, 2021 · In recent years, the conceptualization of addiction as a brain disease has come under increasing criticism. When first put forward, the brain disease view was mainly an attempt to articulate an effective response to prevailing nonscientific, moralizing, and stigmatizing attitudes to addiction. According to these attitudes, addiction was simply ...

    • Markus Heilig, James MacKillop, James MacKillop, Diana Martinez, Jürgen Rehm, Lorenzo Leggio, Louk J...
    • 10.1038/s41386-020-00950-y
    • 2021
    • 2021/09

  5. ajp.psychiatryonline.org › doi › 10Neuroscience of Addiction: Relevance to Prevention and ...

    Apr 25, 2018 · Increased signaling in these circuits triggers aversive symptoms that render the individual vulnerable to cravings and preoccupation with taking the drug as means to counteract this aversive state. In parallel, the dopamine reward/motivation system is hypofunctional, contributing to anhedonia and the aversive state during withdrawal .

    • Nora D. Volkow, Maureen Boyle
    • 2018

  6. Videos

    View all

  7. www.ncbi.nlm.nih.gov › books › NBK597351Neurobiology of Addiction - StatPearls - NCBI Bookshelf

    Nov 2, 2023 · Thus, early substance use may increase vulnerability to addictive disorders by hastening the neuroadaptions in the addiction cycle. Significantly, molecular changes in neuronal support cells, such as microglia and astrocytes, impact the addiction cycle.

    • Abdo Semaan, Mashal K. Khan
    • 2023/11/02

  8. www.nature.com › articles › s41583/022/00656-8The Genetically Informed Neurobiology of Addiction (GINA ...

    Nov 29, 2022 · Here, we highlight the utility of genetically informed study designs to probe the plausibility of proposed models of addiction. Last, we integrate genetic research into an expanded version of the ...

  9. www.mdpi.com › 2813/1851/3-1 › 3Neurobiological Theories of Addiction: A Comprehensive Review

    Jan 23, 2024 · However, the opponent-process theory falls short in explaining individual variability in addiction vulnerability, that is, why not all individuals with repeated exposure to a drug develop addiction. Moreover, it does not make any reference to the involved brain mechanisms.