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Most explanations focus on particular traits, while neglecting others, or on the possible selective factors involved in domestication rather than the underlying developmental and genetic causes of these traits. Here, we propose that the domestication syndrome results predominantly from mild neural crest cell deficits during embryonic development.
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Jul 1, 2014 · Adam S Wilkins, Richard W Wrangham, W Tecumseh Fitch, The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics, Genetics, Volume 197, Issue 3, 1 July 2014, Pages 795–808, https://doi.org/10.1534/genetics.114.165423
- Adam S. Wilkins, Adam S. Wilkins, Richard W. Wrangham, Richard W. Wrangham, W. Tecumseh Fitch
- 2014
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Dec 22, 2020 · It is based on the hypothesis that the domestication syndrome may occur due to genetic (mutations, polymorphisms) and epigenetic changes that occur in early development (e.g., under the influence of hormones) before activation of genes involved in the putative specific networks whose altered expression leads to phenotypic traits of ...
- Goran Šimić, Vana Vukić, Janja Kopić, Željka Krsnik, Patrick R Hof
- 10.3390/biom11010002
- 2020
- Biomolecules. 2021 Jan; 11(1): 2.
factors involved in domestication rather than the underlying developmental and genetic causes of these traits. Here, we propose that the domestication syndrome results predominantly from mild neural crest cell deficits during embryonic development.
- Introduction
- Animal Domestication Is A Multi-Stage Process
- Defining The Term “Domestication Syndrome”
- Tying The Domestication Syndrome to The Neural Crest
- On Testing The Ncds Hypothesis
- Summary and Conclusions
- Acknowledgments
Our 2014 hypothesis, published in GENETICS, aimed to elucidate a set of traits associated with mammalian domestication, a phenomenon termed the “domestication syndrome.” Our explanation focused on a special group of cells found in embryos, the neural crest cells (NCCs) and we proposed that genetic changes affecting their development were at the roo...
All traditional domesticated animals (such as dogs, cattle, sheep, goats, pigs, camels, horses, and chickens) began the process of domestication a long time ago, frequently millennia in the past (Francis 2015). Each of these species almost certainly experienced two semi-distinct stages in their domestication (Zeder 2015; Pendleton et al. 2018). The...
The term “domestication syndrome” has been applied for about four decades to a set of correlated changes in “domesticated” plants, namely crop plants. We use it to refer to a suite of changes in mammals and birds—but which probably occurs in vertebrates including fishes—that distinguish many different domesticated animals from their wild relatives....
The question that motivated our paper was: “why these traits in particular?” Our starting point was realizing that many of the tissues involved in the traits of the domestication syndrome derive from the neural crest. These NCC-derived tissues include major parts of the jaws and teeth, pigmentation cells, components of the external ears, and cells ...
We were pleased to see the following comment in Johnsson et al.: “An upside of the neural crest cell hypothesis of domestication is that it has increased the interest in development amongst domestication researchers” (Johnsson et al. 2021). If a hypothesis promotes research and new thinking, it has real worth, independent of its ultimate fate. Inde...
The scientific study of the animal domestication has a long history, beginning with Darwin’s opus on heredity published in 1868. In that same year, NCCs were first described by the distinguished German embryologist Wilhelm His (His 1868). Our 2014 article brought these two subjects together in the NCDS hypothesis. Here, we have addressed the critiq...
We are grateful to the editors of GENETICS for the opportunity to reply to Johnsson et al.and thank Rich Schneider, Nathalie Feiner, and two anonymous referees for helpful comments on an earlier draft of this article. We also thank Vladislav Nachev for doing the search for usage of the term “domestication syndrome.”
- Adam S Wilkins, Richard Wrangham, W Tecumseh Fitch
- 2021
Feb 11, 2022 · The “domestication syndrome” refers to an apparently disconnected set of phenotypic traits that appear to characterize domesticated species, in comparison with their wild relatives.
The "domestication syndrome" in mammals: a unified explanation based on neural crest cell behavior and genetics. Genetics. 2014 Jul;197 (3):795-808. doi: 10.1534/genetics.114.165423. Epub 2014 Jul 14. Authors. Adam S Wilkins 1 , Richard W Wrangham 2 , W Tecumseh Fitch 3. Affiliations.
