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Cyclic adenosine monophosphate (3′,5′-cyclic AMP or cAMP) is a key component of prokaryotic and eukaryotic intracellular signaling pathways, and the enzyme responsible for its synthesis is adenylyl cyclase (AC). In eukaryotes cAMP primarily activates protein kinase A (PKA), which regulates many enzymes, secondary kinases, transcription ...
The cAMP/PKA pathway. There are three main effectors of cAMP: PKA, the guanine-nucleotide-exchange factor (GEF) EPAC and cyclic-nucleotide-gated ion channels. Protein kinase (PKA), the best-understood target, is a symmetrical complex of two regulatory (R) subunits and two catalytic (C) subunits (there are several isoforms of both subunits).
- Paolo Sassone-Corsi
- 10.1101/cshperspect.a011148
- 2012
- 2012/12
Feb 16, 2022 · Feb. 16, 2022. Cyclic adenosine 3,5-monophosphate, known as cAMP, acts as what the Nobel prize–winning neuroscientist Paul Greengard called a “second messenger” in regulating cellular functions such as growth and specialization, protein expression, and gene transcription by relaying extracellular signals to the cell’s interior.
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cAMP-dependent pathway. In the field of molecular biology, the cAMP-dependent pathway, also known as the adenylyl cyclase pathway, is a G protein-coupled receptor -triggered signaling cascade used in cell communication. [1]
Mar 6, 2008 · Figure 1. The regulation of cyclic AMP (cAMP) levels and antimicrobial actions. The binding of an agonist to the G protein–coupled receptor (GPCR) induces a conformational change resulting in the liberation of the Gα subunit from the βγ subunit complex. The binding of the Gα subunit to adenylyl cyclase (AC) either stimulates (Gαs) or ...
- Carlos H. Serezani, Megan N. Ballinger, David M. Aronoff, Marc Peters-Golden
- 10.1165/rcmb.2008-0091TR
- 2008
- 2008/08
Apr 27, 2010 · This resource provides and describes two animated lessons that illustrate the adenosine 3′,5′-monophosphate (cAMP) signal transduction pathway. They are designed for any collegiate-level course that presents the basic steps of the prototypical pathway. Courses that might employ these animations include Introductory Biology, Molecular ...
May 3, 2021 · 1. Introduction. Cyclic AMP (cyclic 3′,5′-adenosine monophosphate; cAMP) is a second messenger molecule present in almost all living organisms, which plays a pivotal role in cell signaling and modulates a variety of cellular responses. cAMP was first discovered to mediate the effects of hormones in mammalian cells [] and later demonstrated to regulate signaling pathways critical for ...
