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- Tissue plasminogen activator (tPA) is a drug given through a vein to help break up a blood clot so that blood flow can return to normal. It is used for the emergency treatment of ischemic stroke, which occurs when a blood clot interrupts blood flow to a region of the brain. The timely administration of tPA can save lives.
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What is tissue plasminogen activator (tPA)?
What is tissue plasminogen activator?
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Oct 6, 2023 · Tissue plasminogen activator (tPA) is a drug given through a vein to help break up a blood clot so that blood flow can return to normal. It is used for the emergency treatment of ischemic stroke, which occurs when a blood clot interrupts blood flow to a region of the brain.
Feb 20, 2023 · Tissue plasminogen activator (tPA) is classified as a serine protease (enzymes that cleave peptide bonds in proteins). It is thus one of the essential components of the dissolution of blood clots.
- Talha N. Jilani, Abdul H. Siddiqui
- 2023/02/20
- 2019
Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. It acts as an enzyme to convert plasminogen into its active form plasmin, the major enzyme responsible for clot breakdown. It is a serine protease (EC 3.4.21.68) found on endothelial cells lining the blood vessels.
Feb 6, 2023 · Tissue plasminogen activator (tPA) is a type of medication that removes a blood clot to restore blood flow to the brain. Doctors can administer tPA to someone experiencing an ischemic stroke. They typically administer it through an IV up to 4.5 hours after stroke symptoms start.
- Rebekah Louise
Mar 28, 2023 · Tissue plasminogen activator (tPA) is a medication that doctors administer following a stroke caused by a blood clot. It breaks up the blood clot to allow blood flow to return to the brain.
- Karen Veazey
Another major advance was the clot-dissolving medicine tPA (for tissue plasminogen activator), the first treatment for acute ischemic stroke to receive Food and Drug Administration (FDA) approval.
Background and Purpose—The benefits of intravenous tissue-type plasminogen activator (tPA) in acute ischemic stroke are time-dependent, and guidelines recommend a door-to-needle time of ≤60 minutes.
