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Dec 1, 2021 · A large body of evidence, including decades of research on lead and child IQ, indicate a link between toxic environmental exposures and poorer neurodevelopmental outcomes. 5 In animal models and human studies, several toxic chemicals have been implicated in ASD and ASD-related traits and biological markers. 2 Specifically, scientists have found ...
Environmental chemical exposures are increasingly understood to be important in causing autism, with current theories positing that autism is caused by the interplay of multiple genetic and environmental contributions that differ from individual to individual. 4,5 While initial studies suggested a strong genetic heritability of autism, recent ...
- Amy E. Kalkbrenner, Rebecca Jean Schmidt, Annie C. Penlesky
- 10.1016/j.cppeds.2014.06.001
- 2014
- 2014/11
Feb 11, 2014 · Exposures to environmental toxicants such as mercury, lead, arsenic, polychlorinated biphenyls (PCBs) and toluene are known causes of neurodevelopmental disorders. 9 Approximately 85 000 chemicals have been manufactured in the United States, and although only about 2800 are used in high volumes (more than one million pounds produced per year ...
- D A Rossignol, S J Genuis, R E Frye
- 10.1038/tp.2014.4
- 2014
- Transl Psychiatry. 2014 Feb; 4(2): e360.
Mar 13, 2020 · In this review, we aim to delineate the state-of-the-art main research findings about the neurochemical alterations in autism etiology, and focuses on gamma aminobutyric acid (GABA) and glutamate, serotonin, dopamine, N-acetyl aspartate, oxytocin and arginine-vasopressin, melatonin, vitamin D, orexin, endogenous opioids, and acetylcholine.
- Rosa Marotta, Maria C. Risoleo, Giovanni Messina, Lucia Parisi, Marco Carotenuto, Luigi Vetri, Miche...
- 2020
May 17, 2021 · Toxicogenomic analyses suggest disorder-associated exposures may perturb known ASD susceptibility genes through mutagenetic chemical-gene interactions , however a paucity of evidence limits the ...
- Kealan Pugsley, Stephen W Scherer, Mark A Bellgrove, Ziarih Hawi
- 2021
In this review, we covered studies of autism and estimates of exposure to tobacco, air pollutants, volatile organic compounds and solvents, metals (from air, occupation, diet, dental amalgams, and thimerosal-containing vaccines), pesticides, and organic endocrine-disrupting compounds such as flame retardants, non-stick chemicals, phthalates, and...
Such research is in its infancy, and scientists caution that it’s too early to say that pollution or chemicals cause autism just because they occur together. Some recent environmental studies are exploratory in nature: scientists are looking for clues that warrant a more intensive look in future studies.
