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Jan 6, 2010 · In 1950 he married Cornelia Langer, a former student of the sculptor David Smith. The marriage ended in divorce, as did his second and third marriages, to Stephanie Gordon and Peggy Schiffer,...
Nov 4, 2000 · Dr. Reis is survived by his wife, Cornelia Langer Noland Reis; two stepdaughters, Lyn and Cady Noland of Manhattan; a stepson, William Noland of Durham, N.C.; and a granddaughter. Share full...
Cornelia de Lange syndrome (CdLS) is a developmental disorder that affects many parts of the body. The severity of the condition and the associated signs and symptoms can vary widely, but may include distinctive facial characteristics, growth delays, intellectual disability and limb defects.
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What does Cornelia de Lange Syndrome look like?
What is the life expectancy of a child with Cornelia de Lange syndrome?
What are the complications of Cornelia de Lange syndrome?
- Overview
- Symptoms and Causes
- Diagnosis and Tests
- Management and Treatment
- Prevention
- Outlook / Prognosis
Cornelia de Lange syndrome (CdLS) is a rare genetic condition that causes various physical, cognitive and behavioral traits. It affects many parts of your child’s body, so symptoms vary widely. The most common signs of the disorder include delayed growth and distinct facial features. A mutation in one of seven genes typically causes the disease.
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OverviewSymptoms and CausesDiagnosis and TestsManagement and TreatmentPreventionOutlook / Prognosis
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What are the signs and symptoms of Cornelia de Lange syndrome?
Cornelia de Lange syndrome looks like something different for each person affected by it. The condition can affect many different parts and systems of your child’s body. If your child has the condition, they may have the following features:
What causes Cornelia de Lange syndrome?
A harmful change (pathogenic variant) in one of seven genes is the usual cause of Cornelia de Lange syndrome. These genes are NIPBL, SMC1A, HDAC8, RAD21, SMC3, BRD4 and ANKRD11. They’re responsible for the structure and function of the cohesin complex. The cohesin complex is a group of proteins that play an important role in your child’s development before birth. Among other functions, the cohesin complex controls the activity of certain genes responsible for the development of your child’s limbs, face and other body parts. A pathogenic variant in one of these genes impairs the function of the cohesin complex, which interferes with early development. About 60% to 80% of all people with Cornelia de Lange syndrome have a mutation in the NIPBL gene. Mutations in the six other genes are less common. In 5% to 20% of people with the condition, the genetic cause is unknown. Most people with the condition don’t have a family history of the disorder, but if a parent has a mild form of the condition and has children, the chance could be as high as 50% to have a child with the condition. If two unaffected parents have a child with Cornelia de Lange, the chance to have another child with the condition is estimated to be 1% to 1.5%.
What complications can arise from Cornelia de Lange syndrome?
Cornelia de Lange syndrome affects many different parts of your child’s body. Therefore, various complications can occur. These may include:
How is Cornelia de Lange syndrome diagnosed?
Your child’s healthcare provider may be able to diagnose Cornelia de Lange syndrome at birth or shortly thereafter. They’ll perform a physical exam, evaluate your child’s symptoms and ask about your family history. Diagnosis of the condition can be more difficult if your child’s symptoms are mild. Your child’s healthcare provider may request genetic testing to verify their diagnosis. Rarely, your provider can diagnose the disorder before birth. Prenatal genetic testing can identify gene mutations for the condition.
How is Cornelia de Lange syndrome treated?
Treatment for Cornelia de Lange syndrome varies based on your child’s specific symptoms. Because the condition can affect many different parts of your child’s body, a team of healthcare providers may help with treatment. Treatment may include:
How can I prevent Cornelia de Lange syndrome?
You can’t prevent Cornelia de Lange syndrome since it’s a genetic condition. If you plan on becoming pregnant and want to understand your risk of having a child with a genetic condition, talk to your healthcare provider about genetic testing or genetic counseling.
What is the life expectancy for Cornelia de Lange syndrome?
Life expectancy is somewhat normal for people with Cornelia de Lange syndrome. Most children with the condition live well into adulthood. But if your child has certain features of the disease, they may decrease life expectancy. These features include heart and throat defects. Adults with Cornelia de Lange syndrome may need continuing medical care throughout their lives. If complications develop, the prognosis (outlook) depends on the severity and treatment of that condition. A note from Cleveland Clinic Finding out your baby has a rare genetic disorder can be heartbreaking. But most children with Cornelia de Lange syndrome lead full lives and live well into adulthood. When you find out about your child’s disease, your child’s healthcare provider will walk you through various treatment options. You may work with a team of specialists. Make sure you learn all you can about your child’s condition so you can be an advocate for them in getting them the best care possible. Medically Reviewed Last reviewed by a Cleveland Clinic medical professional on 07/12/2023. Learn more about our editorial process.
Apr 14, 1985 · Cornelia Langer Noland, the co- owner of Nuevo Mundo, a boutique in Alexandria, Va., was married yesterday to Dr. Donald Jeffery Reis, the George C. Cotzias Distinguished Professor of Neurology...
Cornelia Langer Noland and Donald Jeffrey Reis in 1985, we immediately packed our bags for a trip to New York just to be sure that the big event really happened. And happen it did. If there had ever been any doubt that Don would devote himself to anyone as much as he devoted himself to his work, all doubt faded with his marriage to Cornelia ...
Cornelia de Lange syndrome is a developmental disorder that affects many parts of the body. The features of this disorder vary widely among affected individuals and range from relatively mild to severe. Cornelia de Lange syndrome is characterized by slow growth before and after birth leading to short stature; intellectual disability that is ...
