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   What is severe sepsis?

   • Sepsis causes an inflammatory response in your body. Severe sepsis occurs when one or more of your body’s organs is damaged from this inflammatory response. Any organ can be affected, your heart, brain, kidneys, lungs, and/or liver. The symptoms you can experience are based on which organ or organs that are affected.

   Severe Sepsis | Sepsis Alliance

   www.sepsis.org/sepsis-basics/what-is-sepsis/severe-sepsis/

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   Do we need a definition of sepsis?

   • Thus, the public needs an understandable definition of sepsis, whereas health care practitioners require improved clinical prompts and diagnostic approaches to facilitate earlier identification and an accurate quantification of the burden of sepsis.

   The Third International Consensus Definitions for Sepsis and Septic

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4968574/

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   What changes have been made to the definition of severe sepsis?

   • The most important changes are the elimination of the terms “SIRS” and “severe sepsis.” Sepsis is now defined as a life-threatening organ failure caused by the host’s inappropriate response to infection.

   SEPSIS DEFINITION: WHAT’S NEW IN THE TREATMENT GUIDELINES

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9536156/

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2. www.nejm.org › doi › fullSevere Sepsis and Septic Shock | New England Journal of Medicine

   www.nejm.org › doi › full

   Aug 29, 2013 · In 1992, an international consensus panel defined sepsis as a systemic inflammatory response to infection, noting that sepsis could arise in response to multiple infectious...

3. www.sepsis.org › what-is-sepsis › severe-sepsisSevere Sepsis | Sepsis Alliance

   www.sepsis.org › what-is-sepsis › severe-sepsis

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   Severe sepsis is a life-threatening condition that occurs when an infection damages vital organs. Learn the symptoms, causes, risk factors, and treatment of severe sepsis from Sepsis Alliance, a nonprofit organization dedicated to sepsis awareness and prevention.

4. www.who.int › news-room › fact-sheetsSepsis - World Health Organization (WHO)

   www.who.int › news-room › fact-sheets

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   May 3, 2024 · Sepsis is a serious condition that happens when the body’s immune system has an extreme response to an infection. It can lead to septic shock, multiple organ failure and death. Learn about the common causes, signs and symptoms, prevention and treatment of sepsis from WHO.

5. www.mayoclinic.org › diseases-conditions › sepsisSepsis - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › sepsis

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   Feb 10, 2023 · Sepsis is a serious condition in which the body responds improperly to an infection. Learn about the symptoms, causes, risk factors and complications of sepsis and septic shock.

6. www.ncbi.nlm.nih.gov › pmc › articlesThe Third International Consensus Definitions for Sepsis and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 2, 2016 · The task force concluded the term severe sepsis was redundant. RECOMMENDATIONS. Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.

   • Author: Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annan...
   • DOI: 10.1001/jama.2016.0287

   • Publish Year: 2016
   • Published: 2016/02/02

7. jamanetwork.com › journals › jamaThe Third International Consensus Definitions for Sepsis and ...

   jamanetwork.com › journals › jama

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   Feb 23, 2016 · Under the new definition, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, where organ dysfunction is defined as an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. 1.

8. www.ncbi.nlm.nih.gov › pmc › articlesSEPSIS DEFINITION: WHAT’S NEW IN THE TREATMENT GUIDELINES

   www.ncbi.nlm.nih.gov › pmc › articles

   Sepsis is defined as the systemic immune response syndrome (SIRS). In addition to sepsis, the term severe sepsis is defined as sepsis associated with organic dysfunction, hypoperfusion and hypotension, and the term septic shock as a condition of sepsis with arterial hypotension insensitive to fluid replacement.