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All roles for the series are cast without the characters' races being pre-specified, in keeping with Rhimes' vision of diversity. The series' protagonist, Meredith Grey, is portrayed by Ellen Pompeo. Pompeo starred in the leading role in Moonlight Mile, which led to her being cast as Meredith.
- Ellen Pompeo as Meredith Grey. The titular character of Grey's Anatomy, audiences were introduced to Meredith Grey on the morning of her first day as an intern at Seattle Grace hospital.
- James Pickens Jr. as Richard Webber. Richard Webber was introduced on the first episode of the series. As the former Chief of Surgery, Richard immediately recognized Meredith's talent and lineage, having worked with her mother, Ellis Grey (Kate Burton).
- Chandra Wilson as Miranda Bailey. Miranda Bailey was introduced to viewers as "The Nazi" for her stern demeanor and refusal to take any nonsense on the series premiere.
- Justin Chambers as Alex Karev. Justin Chambers portrayed Alex Karev, the cocky, overconfident intern who had the nerve to call Meredith a nurse on the first episode.
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Jan 10, 2020 · After over a decade, here's what the original cast of "Grey's Anatomy" is up to now.
- Elana Rubin
Feb 17, 2024 · The 'Grey's Anatomy' cast is returning for season 20! Join EW as we look back on the series' biggest stars throughout the years, including Ellen Pompeo, Patrick Dempsey, and more.
- Every Star Who's Left 'Grey's Anatomy': Where Are They Now? The night … was March 27, 2005. Television titan Shonda Rhimes knew what she had just created — but audiences still had no idea.
- Every Star Who's Left 'Grey's Anatomy': Where Are They Now? The night … was March 27, 2005. Television titan Shonda Rhimes knew what she had just created — but audiences still had no idea.
- Kelly McCreary (Dr. Maggie Pierce) The actress confirmed in March 2023 that she was leaving the medical drama after almost a decade. "After nine seasons, I am saying goodbye to Maggie Pierce and her Grey Sloan family,” she told Entertainment Tonight at the time.
- Richard Flood (Cormac Hayes) When: Season 18, Episode 10. How: Hayes quit his job at Grey Sloan Memorial after a near-fatal car accident with Owen and Teddy.
Jun 26, 2023 · From the mind of Shonda Rhimes, Grey's Anatomy is TV's Longest Running Medical Drama. What Happened to Grey's Alumni and Where Are They Now?
Grey's Anatomy is an American television medical drama series created by Shonda Rhimes and broadcast by ABC. The show features an ensemble cast of lead characters, along with multiple supporting cast members. During its first season, the show featured nine lead characters.
