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Apr 6, 2017 · Tau is well established as a microtubule-associated protein in neurons. However, under pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death in a range of neurodegenerative disorders, collectively referred to as tauopathies.
Jul 14, 2023 · Anne Trafton | MIT News Office. Publication Date. July 14, 2023. Press Inquiries. Caption. In the Alzheimer’s affected brain, abnormal collections of the tau protein accumulate and form tangles (seen in blue) within neurons, harming synaptic communication between nerve cells. Credits. Image: National Institute on Aging, NIH. Caption.
Jun 14, 2010 · Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules.
Feb 3, 2023 · Simple Summary. Tau is an important protein for maintaining the shape and normal function of nerve cells. There are many diseases that are identified by changes in this protein, yet examination of tau in these diseases shows robust differences in tau modifications.
Feb 11, 2019 · The microtubule (MT)-associated protein tau (MAPT) is an intrinsically disordered protein expressed at its highest levels in neurons throughout the central nervous system.
Oct 24, 2023 · The limited success of amyloid-β-targeting therapies for Alzheimer disease (AD) has led to a shift in focus towards the tau protein — the main component of the neurofibrillary tangles that...
Introduction. Two proteins are currently the main focus of research of Alzheimer’s disease (AD) development: tau and amyloid beta (Aβ) ( Figs. 8.1 and 8.2) ( Panza et al., 2014; Mondragón-Rodríguez et al., 2012a; Tran and Ha-Duong, 2015; Iqbal et al., 2014 ).
