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- Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, which may be either the best present in a population, or may be the theoretically optimal genotype.
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Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, which may be either the best present in a population, or may be the theoretically optimal genotype. The average individual taken from a population with a low genetic load will generally, when grown in the same ...
Feb 8, 2022 · The term genetic load was introduced in 1950 (ref. 4 ). With a focus on the phenotypic effect, it is defined as “the proportion by which the population fitness is decreased in comparison with...
- Giorgio Bertorelle
Jul 12, 2023 · Genetic load, a term first introduced by J.B.S. Haldane in 1957, refers to the reduction in a population’s average fitness as a result of deleterious mutations or the accumulation of disadvantageous genes [8]. This concept is critical for understanding how populations evolve and adapt, as well as for predicting potential threats to population ...
Jan 1, 2021 · Definition. Genetic load describes the fitness burden resulting (principally) from deleterious mutations that accumulate within an organism’s genome and is estimated relative to a hypothetical mutation-free or fitness-optimized genome. Individual differences in mutation load, especially with respect to pleiotropic mutations, may be a major ...
- Michael.Woodley@vub.ac.be
May 12, 2015 · Mutation load is the component of genetic load that is attributable to the reduction in fitness caused by recent deleterious mutations.
- Brenna M. Henn, Laura R. Botigué, Carlos D. Bustamante, Andrew G. Clark, Simon Gravel
- 2015
Feb 8, 2022 · The term genetic load was introduced in 1950 (ref.4). With a focus on the phenotypic effect, it is defined as “the proportion by which the popula tion fitness is decreased in comparison with an...
This mathematical theory described the expected mutational load under idealized genetic models whereby deleterious mutations reduce the reproductive success of carriers compared to a hypothetical genotype with no such deleterious variation.
