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Von Willebrand disease (VWD) is a common bleeding disorder, affecting males and females equally, that often manifests in mucosal bleeding. VWD can be secondary to a quantitative (Type 1 and Type 3) or qualitative (Type 2) defects in Von Willebrand factor.
- Angela C. Weyand, Veronica H. Flood
- 2021/12
- 10.1016/j.hoc.2021.07.004
Nov 24, 2016 · Von Willebrand’s disease is subdivided into types 1, 2, and 3. 11 Type 1, which accounts for 70 to 80% of cases, is characterized by a quantitative deficiency of von Willebrand factor.
- Frank W G Leebeek, Jeroen C J Eikenboom
- 2016
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Dec 9, 2022 · Type 1 VWD is the most common subtype, with most patients with plasma VWF levels in the 30- to 50-IU/dL range (low VWF). Focusing on type 1 VWD, we discuss some of the common clinical scenarios faced by health care providers and our approach to their management. CLINICAL CASE 1.
Von Willebrand disease is classified into 3 main types: Type 1: A quantitative deficiency of VWF, which is the most common form and is an autosomal dominant disorder. VWD concentration and activity are both reduced proportionally.
Nov 18, 2014 · According to the National Heart, Lung, and Blood Institute (NHLBI) Guidelines 2 and a recent publication by the British Committee for Standards in Haematology, 3 a definitive diagnosis of type 1 VWD requires a VWF ristocetin cofactor (VWF:RCo) and/or a VWF antigen (VWF:Ag) of < 30 IU dL -1.
- Robert Montgomery, Jonathan Roberts, Gilbert C. White Ii
- 2014
Apr 26, 2017 · Type 1 VWD represents the majority of cases and results from a partial quantitative deficiency of von Willebrand factor (... Controversies in the diagnosis of Type 1 von Willebrand disease - Bowman - 2017 - International Journal of Laboratory Hematology - Wiley Online Library
Type 1 accounts for about 70% of all cases of VWD. It is caused by a mutation in the VWF gene that leads to not enough VWF being synthesized, and classically pre- sents as mild mucocutaneous bleeding.14Most patients have autosomal dominant missense mutations with incomplete penetrance and variable expression.15,16.
