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1. • • A 70-year-old man with type 2M von Willebrand disease (VWD) has failed to attend for a number of years and now requires a right total knee replacement (TKR).
     ashpublications.org › hematology › article

     Perioperative management of patients with von Willebrand disease

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   Does a 70-year-old man with type 2M von Willebrand disease need a knee replacement?

   • A 70-year-old man with type 2M von Willebrand disease (VWD) has failed to attend for a number of years and now requires a right total knee replacement (TKR).

   Perioperative management of patients with von Willebrand disease

   ashpublications.org/hematology/article/2019/1/604/422564/Perioperative-management-of-patients-with-von

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   What is type 2 von Willebrand disease (vWD)?

   • Type 2 von Willebrand disease (VWD) includes a wide range of qualitative abnormalities of von Willebrand factor structure and function resulting in a variable bleeding tendency. According to the current classification, 4 different subtypes can be identified, each with distinctive phenotypic and therapeutic characteristics.

   How I treat type 2 variant forms of von Willebrand disease

   ashpublications.org/blood/article/125/6/907/34067/How-I-treat-type-2-variant-forms-of-von-Willebrand

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   Is von Willebrand disease inherited?

   • Quantitative (types 1 and 3) or qualitative defect of VWF (type 2) cause von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder. 5 Almost all cases identified by epidemiological investigations are type 1, and no data are available for type 2.

   How I treat type 2 variant forms of von Willebrand disease

   ashpublications.org/blood/article/125/6/907/34067/How-I-treat-type-2-variant-forms-of-von-Willebrand

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3. ashpublications.org › hematology › articlePerioperative management of patients with von Willebrand disease

   ashpublications.org › hematology › article

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   Dec 6, 2019 · A 70-year-old man with type 2M von Willebrand disease (VWD) has failed to attend for a number of years and now requires a right total knee replacement (TKR).

   • Author: James S. O’Donnell, Michelle Lavin

   • Publish Year: 2019

4. ashpublications.org › blood › articleHow I treat type 2 variant forms of von Willebrand disease

   ashpublications.org › blood › article

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   Feb 5, 2015 · A 70-year-old male with VWD type 2M VWD (FVIII:C 15 IU/dL, VWF:Ag 12 IU/dL, VWF:RCo 6 IU/dL, VWF:CBA 12 IU/dL, and RIPA 1.7 mg/mL) due to C1315L mutation requires major abdominal surgery because of an adenocarcinoma of the sigmoid colon.

   • Author: Alberto Tosetto, Giancarlo Castaman

   • Publish Year: 2015

5. www.ncbi.nlm.nih.gov › pmc › articlesAcquired von Willebrand syndrome: focused for hematologists

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 14, 2020 · A 70-year old man presented to the emergency room of the main Mantua city hospital in north east Italy with spontaneous gingival bleeding. Apart from mild fatigue and headache, the patient felt well, with no bruising or other hemorrhagic symptoms.

   • Author: Massimo Franchini, Pier Mannuccio Mannucci
   • DOI: 10.3324/haematol.2020.255117

   • Publish Year: 2020
   • Publication: Haematologica. 2020 Aug; 105(8): 2032-2037.

6. www.hmpgloballearningnetwork.com › site › jicvon Willebrand Disease and Coronary Artery Disease: A ...

   www.hmpgloballearningnetwork.com › site › jic

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   Type 2M disease is associated with defective vWF-dependent platelet adhesion. The Type 2N variant results from a decreased affinity of vWF to Factor VIII, which is required for the latter’s survival in vivo.

7. journals.lww.com › hemasphere › FulltextNew Developments in Diagnosis and Management of Acquired ...

   journals.lww.com › hemasphere › Fulltext

   Mar 15, 2021 · Acquired hemophilia A is defined as an acquired severe bleeding tendency caused by autoantibody formation against coagulation factor VIII. Acquired von Willebrand syndrome is characterized by a new onset bleeding tendency caused by a reduced concentration and/or function of von Willebrand factor.

8. ashpublications.org › blood › articleHow I treat gastrointestinal bleeding in congenital and ...

   ashpublications.org › blood › article

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   Sep 3, 2020 · Patients with congenital type 3, 2A, and 2B are those most frequently affected by this symptom, possibly due to the loss of high-molecular-weight multimers of von Willebrand factor (VWF). GI bleeding can also occur in patients affected by acquired von Willebrand syndrome.

9. onlinelibrary.wiley.com › doi › fullHemostatic prophylaxis and colonoscopy outcomes for patients ...

   onlinelibrary.wiley.com › doi › full

   Procedural bleeding occurred after one of six biopsies. The patient who experienced bleeding was a 70-year-old man with mild HA who underwent biopsy of an ulcerated rectal mass. The bleeding was not excessive and did not require intervention.