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- Numerous studies have investigated the relationship between VWF plasma levels and thromboembolic cardiovascular events. In contrast to the rather weak association in the general population, in patients with preexisting vascular disease, VWF is significantly predictive for adverse cardiac events, including death.
www.ahajournals.org › doi › 10Von Willebrand Factor in Cardiovascular Disease | Circulation
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Does von Willebrand factor affect thromboembolic events?
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What is von Willebrand factor (vWF)?
Elevated plasma levels of VWF are associated with established cardiovascular risk factors such as age, 49 smoking, 50 cholesterol, 51 diabetes mellitus, 52 and hypertension. 53 Moreover, raised levels of VWF are predictive of stroke and vascular events among patients with atrial fibrillation. 54 Correspondingly, many studies have investigated ...
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Oct 7, 2021 · Results. Across the spectrum of venous thromboembolic disease, we consistently observed that elevated VWF levels conferred an increased risk of VTE and long-term venous complications. We have highlighted important findings from VWF molecular research and have proposed mechanisms by which VWF participates in venous disease.
- 10.1016/j.jvssci.2021.08.002
- 2022
- JVS Vasc Sci. 2022; 3: 17-29.
The heritable form of von Willebrand Disease was first described nearly a century ago, but more recently, recognition of an acquired condition known as acquired von Willebrand Syndrome (AVWF) has emerged in persons with hematological, endocrine and cardiovascular diseases, disorders and conditions.
- Radha Mehta, Muhammad Athar, Sameh Girgis, Atif Hassan, Richard C. Becker
- 10.1007/s11239-019-01849-2
- 2019
- 2019/07
Aug 28, 2023 · Introduction. Von Willebrand factor is a glycoprotein that plays a part in hemostasis. It is synthesized in endothelial cells and megakaryocytes. After transcription and translation, pro-vWF is covalently linked to form dimers in the endoplasmic reticulum, and subsequently, large dimers form in the Golgi complex and secretory granules.
- Ayan Sabih, Hani M. Babiker
- 2023/08/28
- 2019
Dec 17, 2020 · In particular, ABO affects multiple aspects of von Willebrand factor (VWF) biology. In keeping with their reduced thrombotic risk, plasma VWF levels are ∼25% lower in healthy group O compared with healthy group non-O individuals. In addition, blood group O VWF demonstrates enhanced susceptibility to ADAMTS13 proteolysis.
- Soracha E. Ward, Jamie M. O’Sullivan, James S. O’Donnell, James S. O’Donnell
- 2020
Mar 18, 2008 · von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured atherosclerotic plaque lesions). Numerous studies have investigated the relationship between VWF plasma levels and thromboembolic cardiovascular events.
